阿加曲班联合阿司匹林治疗后循环进展性脑梗死急性期疗效观察

目的评价阿加曲班联合阿司匹林治疗后循环进展性脑梗死急性期的临床疗效。方法选取2017年1月—2017年9月大理大学附属医院收治的后循环进展性脑梗死急性期患者80例,随机分为对照组(40例)和治疗组(40例)。对照组口服阿司匹林肠溶片,1片/次,每晚一次;治疗组在对照组的基础上静脉泵注阿加曲班注射液,60 mg加入生理盐水25 m L,持续48 h,治疗2 d后10 mg加入25 m L生理盐水中,2次/d。两组均治疗14 d。观察两组患者临床疗效,比较治疗前后两组患者国立卫生研究院卒中量表(NIHSS)和BI评分。结果治疗后,对照组和治疗组临床有效率分别为67.5%和87.5%,两组比较差异具有统计学意义(P0.05)。治疗7、14 d后,两组患者NIHSS评分明显降低,BI评分明显升高,同组治疗前后比较差异具有统计学意义(P0.05);且治疗7、14 d后,治疗组NIHSS评分和BI评分明显优于同期对照组,两组比较差异具有统计学意义(P0.05)。结论阿加曲班联合阿司匹林治疗急性脑梗死后循环进展性卒中急性期疗效显著,可促进神经功能恢复,有利于改善日常活动能力。

Clinical observation of argatrob combined with aspirin in treatment of progressive infarcts in posterior circulation

Objective To evaluate the clinical efficacy of argatrob combined with aspirin in treatment of progressive infarcts in posterior circulation. Methods Patients (80 cases) with progressive infarcts in posterior circulation in the First Affiliated Hospital of Dali University from January 2017 to September 2017 were randomly divided into control (40 cases) and treatment (40 cases) groups. Patients in the control group were po administered with Aspirin Enteric-coated Tablets, 1 tablet/time, once every night. Patients in the treatment group were intravenous pumping administered with Argatroban Injection on the basis of the control group, 60 mg added into normal saline 25 mL, maintained for 48 h, and 10 mg added into normal saline 25 mL after treatment for 2 d, twice daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, the NIHSS and BI scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 67.5% and 87.5% respectively, and there were differences between two groups (P<0.05). After treatment for 7 d and 14 d, the NIHSS scores in two groups were significantly decreased, but BI scores were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the NIHSS and BI scores in the treatment group after treatment for 7 d and 14 d were significantly better than those in the control group in the same period, with significant difference between two groups (P<0.05). Conclusion Argatroban combined with aspirin in treatment of progressive infarcts in posterior circulation has an accurate curative effect, which can promote the recovery of nerve function and improve the ability of daily activities.