山绿茶降压片联合依那普利叶酸治疗H型高血压的临床研究

目的探讨山绿茶降压片联合马来酸依那普利叶酸片治疗H型原发性高血压的临床疗效。方法选取2016年9月—2017年9月在濮阳市安阳地区医院进行治疗的H型原发性高血压患者84例,随机分为对照组(42例)和治疗组(42例)。对照组口服马来酸依那普利叶酸片,1片/次,1次/d;治疗组在对照组的基础上口服山绿茶降压片,4片/次,3次/d。两组均治疗4周。观察两组患者临床疗效,同时比较治疗前后两组患者血压变化情况、血清细胞因子水平和血管内皮功能指标。结果治疗后,对照组临床有效率为80.95%,显著低于治疗组的95.24%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者24 h平均收缩压(mSBP)、24 h平均舒张压(mDBP)均明显低于降低(P0.05),且治疗组患者血压明显优于对照组(P0.05)。治疗后,两组患者血清超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、单核细胞趋化蛋白-1(MCP-1)、基质金属蛋白酶-9(MMP-9)水平显著降低(P0.05),且治疗后治疗组血清细胞因子水平明显低于对照组(P0.05)。治疗后,两组血清一氧化氮(NO)水平显著升高(P0.05),内皮素(ET)水平显著降低(P0.05),且治疗组血管内皮功能明显好于对照组(P0.05)。结论山绿茶降压片联合马来酸依那普利叶酸片治疗H型原发性高血压可有效降低血压,降低血清Hcy,改善血管内皮功能,具有一定的临床推广应用价值。

Clinical study on Shanlvcha Jiangya Tablets combined with enalapril and folic acid in treatment of H-type hypertension

Objective To explore the clinical effect of Shanlvcha Jiangya Tablets combined with enalapril and folic acid in treatment of H-type hypertension. Methods Patients (84 cases) with H-type hypertension in Anyang District Hospital from September 2016 to September 2017 were randomly divided into control (42 cases) and treatment (42 cases) groups. Patients in the control group were po administered with Enalapril Maleate and Folic Acid Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Shanlvcha Jiangya Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the change of blood pressure, the serum cytokine levels, the vascular endothelial function indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.95%, which was significantly lower than 95.24% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the 24 h mSBP and 24 h mDBP in two groups was significantly decreased (P<0.05), and the blood pressure in the treatment group after treatment was significantly better than that in the control group (P<0.05). After treatment, the hs-CRP, Hcy, MCP-1 and MMP-9 levels in two groups were significantly decreased (P<0.05), and the serum cytokine levels in the treatment group after treatment were significantly lower than those in the control group (P<0.05). After treatment, the NO levels in two groups were significantly increased (P<0.05), but the ET-1 levels were significantly decreased (P<0.05), and the vascular endothelial function in the treatment group after treatment was significantly better than that in the control group (P<0.05). Conclusion Shanlvcha Jiangya Tablets combined with enalapril and folic acid in treatment of H-type hypertension can effectively reduce blood pressure and serum Hcy levels, and improve vascular endothelial function, which has a certain clinical application value.