雪山金罗汉止痛涂膜剂联合双氯芬酸钠缓释片治疗急性期痛风性关节炎的临床研究

目的探讨雪山金罗汉止痛涂膜剂联合双氯芬酸钠缓释片治疗急性期痛风性关节炎的临床疗效。方法选取2015年1月—2016年12月在天津中医药大学第一附属医院就诊的急性期痛风性关节炎患者60例,随机分为对照组(30例)和治疗组(30例)。两组患者均口服双氯芬酸钠缓释片,75 mg/d,对照组在此基础上涂抹患处双氯芬酸二乙胺乳胶剂,3次/d。治疗组在口服双氯芬酸钠缓释片的基础上患处涂抹雪山金罗汉止痛涂膜剂,3次/d。两组均治疗14 d。观察两组患者临床疗效,同时比较治疗前后两组患者关节功能及血尿酸(UA)、血沉(ESR)和C-反应蛋白(CRP)水平。结果治疗后,对照组临床有效率为70.00%,显著低于治疗组的86.67%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者视觉模拟评分(VAS)及关节压痛、肿胀、活动障碍积分均显著降低(P0.05),且治疗后治疗组上述症状积分均明显低于对照组(P0.05)。治疗后,两组患者CRP和ESR水平均显著降低(P0.05),且治疗后治疗组CRP和ESR水平明显低于对照组(P0.05)。结论雪山金罗汉止痛涂膜剂联合双氯芬酸钠缓释片治疗急性期痛风性关节炎临床有效,可以缓解关节疼痛,减轻炎症反应,改善关节功能。

Clinical study on Xueshan Jinluohan Analgesic Coating Agent combined with Diclofenac Sodium Sustained Release Tablets in treatment of acute gouty arthritis

Objective To observe the clinical efficacy of Xueshan Jinluohan Analgesic Coating Agent combined with Diclofenac Sodium Sustained Release Tablets in treatment of acute gouty arthritis. Methods Patients (60 cases) with acute gouty arthritis in First Teaching Hospital of Tianjin University of Traditional Chinese Medcine from January 2015 to December 2016 were randomly divided into control (30 cases) and treatment (30 cases) groups. Patients in two groups were po administered with Diclofenac Sodium Sustained Release Tablets, 75 mg/time, and patients in the control group were coating administered with Diclofenac Diethylamine Emulgel, three times daily. Patients in the treatment group were coating administered with Xueshan Jinluohan Analgesic Coating Agent on the basis of the control group, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the joint function, UA, CRP, and ESR levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 70.00%, which was significantly lower than 86.67% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the VAS, Joint tenderness, swelling and movement disorders scores in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the CRP and ESR levels in two groups were significantly decreased (P<0.05), and the CRP, ESR levels in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Xueshan Jinluohan Analgesic Coating Agent combined with Diclofenac Sodium Sustained Release Tablets in treatment of acute gouty arthritis is effective, can relieve joint pain, alleviate inflammatory reaction and improve joint function.