| 磁场、噪声、高温复合作用对大鼠热应激蛋白-70表达的影响 |
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| 引用本文： | 徐建华,柯文棋,乐秀鸿,李政年,黄建松,李振杰.磁场、噪声、高温复合作用对大鼠热应激蛋白-70表达的影响[J].中华航海医学与高气压医学杂志,2005,12(2):86-88. |
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| 作者姓名： | 徐建华 柯文棋 乐秀鸿 李政年 黄建松 李振杰 |
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| 作者单位： | 200433,上海,海军医学研究所 |
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| 摘 要： | 目的研究磁场、噪声、高温三因素复合作用对机体热应激蛋白-70(HSP70)表达的影响。方法采用三因素二水平正交方法L8(27)]实验设计,用免疫组化ABC法测定大鼠肝脏、脾脏和脑组织的HSP70表达量。结果磁场对大鼠肝脏、脾脏和脑组织HSP70表达有影响(P<0.01或<0.05);高温对肝脏和脾脏组织中HSP70表达有影响(P<0.05)。结论磁场是影响HSP70表达的主因素,高温有一定的作用,磁场、高温、噪声三因素之间的交互作用不明显。
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| 关 键 词： | 磁场 噪声 高温 正交设计 热应激蛋白-70 |
| 修稿时间： | 2004年9月7日 |
The effect of magnetic field, noise and high temperature on HSP70 expression in rats |
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| XU Jian-hua,KE Wen-qi,LE Xiu-hong,et al..The effect of magnetic field, noise and high temperature on HSP70 expression in rats[J].Chinese Journal of Nautical Medicine and Hyperbaric Medicine,2005,12(2):86-88. |
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| Authors: | XU Jian-hua KE Wen-qi LE Xiu-hong |
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| Institution: | XU Jian-hua,KE Wen-qi,LE Xiu-hong,et al. Naval Medical Research Institute,Shanghai 200433,China |
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| Abstract: | Objective To study the effect of magnetic field,noise and high temperature on heat stress protein 70(HSP70) expression in rats. Methods Three-element two-level orthogonal method was used to design experiments and microcirculatory microscope and other decices was used to test the expression of HSP70 in rats under simulated shipboard environment.Results Magnetic field had influence on the expression of HSP70 in rat liver,rat spleen,and rat brain tissue (P<0.01 or P<0.05). High temperature had influence on the expression of HSP70 in rat liver and rat spleen (P<0.05). Conclusions Magnetic field and high temperature have some influence on the expression of HSP70. Three-element interaction had no significant effect on the expression of HSP70. |
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| Keywords: | Magnetic field Noise High temperature Orthogonal design Heat stress ~protein 70 |
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