| 中药独活化学成分的研究 |
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| 引用本文： | 丁希飞,冯煦,董云发,赵兴增,陈雨,王鸣. 中药独活化学成分的研究[J]. 中药材, 2008, 31(4): 516-518 |
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| 作者姓名： | 丁希飞 冯煦 董云发 赵兴增 陈雨 王鸣 |
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| 作者单位： | 江苏省中国科学院植物研究所/南京中山植物园,江苏南京,210014 |
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| 摘 要： | 目的：研究中药独活的化学成分。方法：应用大孔吸附树脂、ODS等多种柱层析进行分离和纯化,并应用NMR和MS方法解析了其化学结构。结果：从独活80%乙醇提取物中分离得到7个化合物,分别被鉴定为紫花前胡苷元（nodakenetin,Ⅰ）、伞形花内酯（umbelliferone,Ⅱ）、哥伦比亚苷元（columbianetin,Ⅲ）、二氢山芹醇-β-D-葡萄糖苷（β-D-glucosyl-columbianetin,Ⅳ）、哥伦比亚苷（columbianin,Ⅴ）、tert.-O-β-D-glucopy-ranosyl-（R）-byakan-gelicin（Ⅵ）、sec.-O-β-D-glucopyranosyl-（R）-byakangelicin（Ⅶ）。其中Ⅳ、Ⅵ和Ⅶ为首次从该植物中分离得到。
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| 关 键 词： | 独活 伞形科 化学成分 中药 化学成分 研究 Angelica Roots Chemical Constituents 植物 葡萄糖苷 二氢 紫花前胡苷元 哥伦比亚 伞形花内酯 化合物 分离和纯化 乙醇提取物 结果 化学结构 层析 大孔吸附树脂 应用 |
| 文章编号： | 1001-4454(2008)04-0516-03 |
| 修稿时间： | 2007-10-22 |
Studies on Chemical Constituents of the Roots of Angelica pubescens |
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| DING Xi-fei,FENG Xu,DONG Yun-fa,ZHAO Xing-zeng,CHEN Yu,WANG Ming. Studies on Chemical Constituents of the Roots of Angelica pubescens[J]. Journal of Chinese medicinal materials, 2008, 31(4): 516-518 |
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| Authors: | DING Xi-fei FENG Xu DONG Yun-fa ZHAO Xing-zeng CHEN Yu WANG Ming |
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| Affiliation: | Jiangsu Institute of Botany, CAS, Nanjing Botanical Garden Mem Sun Yat-Sen, Nanjing 210014, China. |
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| Abstract: | OBJECTIVE: To study the chemical constituents of the roots of Angelica pubescens. METHODS: Fresh roots of Angelica pubescens were extracted with EtOH,the chemical constituents in the extract were isolated by column chromatography as macroporous absorption resin,and ODS etc. Their structures were confirmed by spectral analysis (NMR, MS). RESULTS: Seven compounds were isolated and their structures were identified as nodakenetin (I), umbelliferone (II), columbianetin (III), beta-D-glucosyl-columbianetin (IV), columbianin (V), tert. -O-beta-D- glucopyranosyl -(R)-by-akangelicin (VI) and sec. -O-beta-D- glucopyranosyl-(R) -byakangelicin (VII). CONCLUSION: Compound IV, VI and VII are isolated from Angelica pubescens for the first time. |
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