| CD4+CD25+调节性T细胞及其分子标记物与支气管哮喘 |
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| 引用本文： | 马祥,毛辉,梁宗安. CD4+CD25+调节性T细胞及其分子标记物与支气管哮喘[J]. 国际呼吸杂志, 2009, 29(7). DOI: 10.3760/cma.j.issn.1673-436X.2009.07.012 |
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| 作者姓名： | 马祥 毛辉 梁宗安 |
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| 作者单位： | 四川大学华西医院呼吸内科,成都,610041;四川大学华西医院呼吸内科,成都,610041;四川大学华西医院呼吸内科,成都,610041 |
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| 摘 要： | CD4+CD25+调节性T细胞是一类以免疫抑制和免疫无能为特征的淋巴细胞群,FOXP3是CD4+CD25+调节性T细胞一个特征性的分子标志物,并且对CD4+CD25+调节性T细胞的发育、外周表达和功能维持有着关键性的作用.近年来,多项研究显示CD4+CD25+调节性T细胞参与并影响了支气管哮喘的发生、发展过程,对调节性T细胞或其相关基因的干预也许会成为支气管哮喘治疗的新方向.
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| 关 键 词： | CD4+CD25+调节性T细胞 FOXP3 哮喘 |
CD4+CD25+regulatory T cell and its molecular marker with bronchial asthma |
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| MA Xiang,MAO Hui,LIANG Zong-an. CD4+CD25+regulatory T cell and its molecular marker with bronchial asthma[J]. International Journal of Respiration, 2009, 29(7). DOI: 10.3760/cma.j.issn.1673-436X.2009.07.012 |
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| Authors: | MA Xiang MAO Hui LIANG Zong-an |
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| Abstract: | CD4+CD25+regulatory T cells are a kind of lymphocytes characterized by immune inhibition and immune inability,FOXP3 is a specific molecular marker of CD4+CD25+regulatory T cells,and critical for the generation,peripheral expression and function of CD4+CD25+regulatory T cells.In recent years,a series of studies showed that CD4+CD25+regulatory T cells interfere with the development and progression of bronchial asthma,the intervention of regulatory T cell and its relative genes may offer a novel therapeutic strategy for bronchial asthma. |
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| Keywords: | FOXP3 |
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