槐耳颗粒对肝癌肝移植术后患者疗效的影响

目的 探讨槐耳颗粒对肝癌肝移植术后患者的辅助治疗效果.方法 将2004年7月至2006年6月符合UCSF标准的肝癌肝移植患者60例分为槐耳颗粒组(20例)、化疗组(15例)、槐耳颗粒+化疗组(15例)和对照组(10例).观察各组的白细胞、肝功能、细胞免疫功能指标、免疫排斥反应情况,并统计术后1年肿瘤复发率.结果 化疗组白细胞在治疗后1、3、6个月较治疗前明显减低(F=62.053,58.472,49.807,P＜0.05);其余3组治疗前后变化不大;4组比较差异有统计学意义(F=102.361,113.412,87.572,P＜0.05).槐耳颗粒组和槐耳颗粒+化疗组NK细胞活性、CD4+/CD8+比值、IL-2水平在治疗后1、3、6个月显著高于治疗前,并显著高于化疗组和对照组(P＜0.05).各组在观察期间均未出现急性免疫排斥反应;术后1年各组均有2例患者出现复发、转移,对照组发生率高于其余3组(P＜0.05).结论 槐耳颗粒能改善肝癌肝移植患者术后化疗所致的白细胞减少,增强患者的细胞免疫功能,能有效抑制肿瘤在术后1年内的复发、转移.

Effects of huaier granule on hepatocellular carcinoma after Hver transplantation

Objective To investigate the auxiliary effects of huaier granule on hepatoeellular carcinoma (HCC)patients after liver transplantation.Methods Sixty HCC patients who had undergone liver transplantation from Julv 2004 to June 2006 and met the standard of UCSF were involved in this study.All patients were divided into huaier granule group(n=20),chemotherapy group(n=15),huaier granule+chemotherapy group (n=15)and control group(n=10).The white blood cell count,liver function,cell immunity and immunologieal reiection were detected.The 1-year tumor recurrence rate wag calculated.Results The white blood cell counts in chemotherapy group 1,3,and 6 months after treatment were significantly lower than that before treatment (F=62.053,58.472,49.807,P＜0.05).The changes of white blood cell counts of the other 3 groups before and aftertreatment were small.The difference on the white blood cell counts of the 4 groups had no statistical 8ignincanee(F=102.361,113.412,87.572,P＜0.05).The NK activity,CD4+/CD8+ ratio,IL-2 level in huaier granule group and huaier granule+chemotherapy group 1,3,6 months after treatment were significantly higher than those before treatment,and were significantly higher than those in chemotherapy group and control group(P＜0.05).No immunological rejection occurred in all the groups.Two patients in each group had recurrence and metastasis of HCC within 1 year after the treatment.and the incidence in control group was higher than the other 3 groups(P＜0.05). Conclusions Humer granule can increase the white blood cell count which is decreased after chemotherapy,impmve cellular immunity,and effectively suppress the recurrence and metastasis of HCC at the first year after operation.