| Bevacizumab对大鼠角膜新生血管的抑制作用 |
| |
| 引用本文： | 荆国利,高晓唯,任兵,肖云. Bevacizumab对大鼠角膜新生血管的抑制作用[J]. 国际眼科杂志, 2008, 8(10) |
| |
| 作者姓名： | 荆国利 高晓唯 任兵 肖云 |
| |
| 作者单位： | 832000,中国新疆维吾尔自治区石河子市,石河子大学医学院研究生院;830011,中国新疆维吾尔自治区乌鲁木齐市,解放军474医院全军眼科中心;解放军474医院全军眼科中心,中国新疆维吾尔自治区乌鲁木齐市,830011 |
| |
| 摘 要： | 目的：评价Bevacizumab抑制大鼠角膜新生血管的效果。方法：碱烧伤诱导角膜新生血管模型，对20只wistar大鼠40眼随机平均分4组。角膜碱烧伤后分别给予结膜下注射药物溶剂和不同剂量Bevacizumab。比较并计算角膜新生血管生长面积。16d后角膜标本行HE检验和免疫组织化学检测VEGF的表达。结果：各用药组与对照组新生血管面积比较差异有统计学意义；治疗组间新生血管面积比较差异没有统计学意义。组织学发现各药物治疗组炎性细胞浸润、新生血管形成均明显轻于对照组。新生血管对照组VEGF染色明显增强，药物注射组表达明显减弱。结论：结膜下注射一定浓度的Bevacizumab对大鼠角膜碱烧伤形成的新生血管有抑制作用。
|
| 关 键 词： | Bevacizumab 角膜新生血管 血管内皮生长因子 |
The inhibitory action of Bevacizumab on rat corneal neovascularization |
| |
| Guo-Li Jing,Xiao-Wei Gao,Bing Ren,Yun Xiao. The inhibitory action of Bevacizumab on rat corneal neovascularization[J]. International Eye Science, 2008, 8(10) |
| |
| Authors: | Guo-Li Jing Xiao-Wei Gao Bing Ren Yun Xiao |
| |
| Abstract: | AIM:To evaluate the anti-angiogenesis action of Bevacizumab on corneal neovascularization(CNV)in rats induced by alkali burns. METHODS:20 Health Wistar rats,aging from 6 to 8 weeks and weighting from 170g to 190g were prepared for CNV animal models.Both corneas of each animal in experimental were cauterized with alkali,then all rats were randomly divided into four groups(each group have 5 rats and 10 corneas),the both corneas of each rats were received subconjunctival Bevacizumab in different dosage(group 2... |
| |
| Keywords: | bevacizumab corneal neovascularization vascular endothelial growth factor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
