葡萄糖酸锌辅助药物治疗精液不良症临床研究

目的　探讨锌对男性不育患者精液质量的影响作用。　方法　以精液不良为主的男性不育症者 992例 ,其中 876例口服 0 .0 5 %葡萄糖酸锌 (A组 ) ,116例口服 10 %葡萄糖酸钙作为对照 (B组 ) ,5 4 8例精液正常者作为正常对照 (C组 )。对比用药前和用药后 4周各组精液参数、精浆和血清锌含量 ,并对其配偶妊娠情况进行随访观察。　结果　A组用药前后精液参数、精浆和血清锌含量相比差异有显著性意义 (P <0 .0 1) ,B组各指标用药前后相比差异无显著性意义 (P >0 .5 ) ,A、B两组间用药后各指标差异有显著性意义 (P <0 .0 0 1) ,C组与A、B两组精浆和血清锌含量相比差异有显著性意义 (P <0 .0 1)。经 10年随访 ,A组妊娠率 5 8.4 % ,B组妊娠率 1.6 % ,两组差异有显著性意义 (P <0 .0 0 1)。B组 112例在第一阶段治疗效果不佳后 ,改用A组方法治疗 ,各指标前后结果相比差异有显著性意义 (P <0 .0 1)。全组治疗过程中未发生严重不良反应。　结论　锌能改善精液质量和增加精浆、血清锌含量。应用葡萄糖酸锌及综合治疗可提高不育症的治愈率。

Clinical study of Zn-complex glucose acid as an adjuvant drug for the treatment of the male infertility due to semen of poor quality

Objective To evaluate zinc therapy in the management of infertility due to semen of poor quality. Methods Oral 0.05% zinc gluconate was instituted to 876 cases of male infertility due to semen of poor quality (group A) and 10% calcium gluconate orally to 116 patients as controls (group B).548 men with normal semen served as normal contrast (group C).Semen routine and zinc content in semen fluid and blood semen were assessed 4 weeks before and 4 weeks after the treatment in all.Their couples were followed up for pregnancy or not. Results There was a significant difference of parameters on semen examination and zinc content in semen fluid and blood serum before and after treatment in group A(P<0.01),whereas there was no such changes in group B (P>0.05).However,there was a significant difference of these parameters between group C and both group B and group A after the drug administration (P<0.001).All of them were followed up for couple pregnancy for 10 years,the pregnancy rate being 58.4% in group A and 1.6% in group B (P<0.001).112 men in group B were converted to the oral intake of zinc gluconate because of non-efficiency with calcium gluconate and the semen parameter and the zinc content because significantly better (P<0.01).No serious adverse reaction has been observed. Conclusions Zinc gluconate in take would improve the semen quality and the zinc content in semen fluid and blood serum,when used together with other treatment would increase the cure rate of male infertility.