Pharmaceutical development of a parenteral formulation of the novel anti-tumor agent carzelesin (U-80,244) |
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Authors: | Jantine D. Jonkman de Vries Marga J. A. de Graaff-Teulen Roland E. C. Henrar Jantien J. Kettenes van den Bosch Auke Bult Jos H. Beijnen |
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Affiliation: | (1) Department of Pharmacy, Slotervaart Hospital/Netherlands Cancer Institute, Amsterdam;(2) European Organization for Research and Treatment of Cancer - New Drug Development Office, Free University Hospital, Amsterdam;(3) Department of Pharmaceutical Analysis, Faculty of Pharmacy, Utrecht University, Utrecht, The Netherlands |
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Abstract: | Summary The aim of this study was to design a parenteral dosage form for the investigational cytotoxic drag carzelesin. A stable formulation in PET (Polyethylene glycol 400/absolute ethanol/Tween 80, 6:3:1, v/v/v) was developed. The prototype, containing 0.50 mg carzelesin in 2.0 ml PET formulation, was found to be the optimal formulation in terms of solubility, stability and dosage requirements in phase I clinical trials. Quality control of the formulation showed that the pharmaceutical preparation of carzelesin in PET is not negatively influenced by the manufacturing process. Shelf life studies demonstrated that the formulation is stable for at least 1 year, when stored at –30°C in the dark. In addition, the stability of carzelesin in the PET formulation is discussed as a function of temperature, additives and after dilution in infusion fluids. |
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Keywords: | carzelesin (U-80,244) analytical characterization parenteral formulation stability degradation products |
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