| Iressa抑制高转移性人肝癌LCI-D20原位移植瘤的血管形成 |
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| 引用本文： | 陈方国,王杰军,薛琼,于观贞,侯亮,郭子姮. Iressa抑制高转移性人肝癌LCI-D20原位移植瘤的血管形成[J]. 中国肿瘤, 2006, 15(10): 691-694 |
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| 作者姓名： | 陈方国 王杰军 薛琼 于观贞 侯亮 郭子姮 |
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| 作者单位： | 1. 第二军医大学附属长征医院,上海,200070
2. 复旦大学附属中山医院肝癌研究所,上海,200032 |
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| 摘 要： | [目的]探讨Iressa对人高转移肝癌模型LCI-D20血管形成的抑制作用。[方法]12只原位移植LCI-D20肿瘤裸鼠分为采用空白对照组（A组）及Iressa治疗组（B组），用药28d后处死裸鼠．测量肿瘤质量，检测肿瘤组织微血管密度（MVD）。[结果]对照组肿瘤负衙平均为2．01／g，MVD平均为39．57个／HP；治疗组平均肿瘤负荷及平均MVD为1．18g、14．10个／HP，与对照组比较差异有显著性（P〈0．05）。[结论]Iressa有抑制肝癌血管形成及肿瘤生长的活性。
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| 关 键 词： | 肝肿瘤 血管形成 血管形成抑制剂 |
| 文章编号： | 1004-0242（2006）10-0691-04 |
| 收稿时间： | 2006-03-16 |
| 修稿时间： | 2006-03-162006-04-21 |
Inhibitive Effect of Iressa on Angiogenesis in LCI-D20 Orthotopically Implanted High Metastatic Human Hepatocellular Carcinoma Model |
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| CHEN Fang-guo, WANG Jie-jun, XUE Qion,et al.. Inhibitive Effect of Iressa on Angiogenesis in LCI-D20 Orthotopically Implanted High Metastatic Human Hepatocellular Carcinoma Model[J]. CHINA CANCER, 2006, 15(10): 691-694 |
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| Authors: | CHEN Fang-guo WANG Jie-jun XUE Qion et al. |
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| Affiliation: | 1.Changzheng Hospital of the Second Military Medical University, Shanghai 200070, China; 2.Affiliated Zhongshan Hospital, Liver Cancer Institute of Fudan University, Shanghai 200032, China |
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| Abstract: | [Purpose] To explore the inhibitive effect of Iressa on angiogenesis of highly metastatic human hepatocellular carcinoma model of LCI-D20.[Methods] Twelve nude mouse via orthotopic implantation of LCI-D20 were randomized into two groups:control group(A group)and Iressa group(B group).Tumor mass and microvessel density(MVD)were measured at the 28th-day of treatment.[Results] The mean tumor mass were 2.01g and 1.18g in A and B group respectively.The mean MVD were 39.57/HP and 14.10/HP in A and B group respectively.There was significant difference between two groups(P<0.05).[Conclusion] Iressa inhibits the growth of tumor and angiogenesis of hepatocellular carcinoma. |
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| Keywords: | Iressa |
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