碘海醇中3-氯-1,2-丙二醇测定方法的改进

目的：建立毛细管柱GC法测定碘海醇中3-氯-1，2-丙二醇残留量的方法。方法：采用OV-1701石英毛细管柱（30m×0．32mm×1．0μm），氢火焰离子化检测器，程序升温，进样口温度230℃，检测器温度250℃。结果：3-氯-1，2-丙二醇在4．982～398．6μg·mL^-1浓度范围内与峰面积呈良好的线性关系（r=0．9997，n=7），加样回收率为80．0％（RSD=6．6％，n=15）；系统适用性溶液回收率应在60％-90％之间，分析了3批样品，第一批样品中未检出，第二批样品中含量为0．0030％，第三批样品中含量为0．0104％。结论：本法专属性强，灵敏度高，结果准确，可很好地控制碘海醇中3-氯-1，2-丙二醇的残留量。

Improvement of Test Method on 3-chloro-1,2-propanediol in Iohexol

Objective： To establish a GC method for the determination of 3-chloro-1,2-propanediol content in Iohexol. Methods： OV- 1701 quartz capillary column（30 m ×0. 32 mm × 1.0 μm） and FID were used. The column temperature was programmed, the inlet temperature was 230℃ and the detector was 250 ℃. Results：The standard curve of 3-chloro-1,2-propanediol had a good linear relationship in the range of 4. 982-398. 6 μg· mL- 1 （r = 0. 9997, n = 7）, the average recovery was 80.0% （ RSD = 6.6% ,n = 15）. The recovery of system suitability solution should be within 60% -90%. Three batches of samples were analyzed and the contents of 3-chlo- ro-1,2-propanediol were none, 0. 0030% and 0. 0104%, separately. Conclusion：The method provided a selective, sensivie and accurate feasible way for controlling the amout of 3-chloro-1,2-propanediol in Iohexol.