医院重症监护病房呼吸道感染患者病原菌种类及耐药状况调查 |
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引用本文: | 葛国兴,王宗欣,王清. 医院重症监护病房呼吸道感染患者病原菌种类及耐药状况调查[J]. 疾病监测, 2013, 28(4): 310-313. DOI: 10.3784/j.issn.1003-9961.2013.4.017 |
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作者姓名: | 葛国兴 王宗欣 王清 |
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作者单位: | 葛国兴 (绍兴市人民医院,浙江绍兴,312000); 王宗欣 (绍兴市人民医院,浙江绍兴,312000); 王清 (绍兴市人民医院,浙江绍兴,312000); |
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摘 要: | 目的 调查浙江省绍兴市人民医院重症监护病房(ICU)常见呼吸系统感染病原菌的种类分布和耐药状况,为临床指导用药和控制医院感染提供依据。 方法 对2010-2011年医院ICU呼吸道感染患者的痰液及深部导管等标本中分离出的病原菌,用专用微生物鉴定仪分析,同时采用K-B纸片扩散法进行病原菌药敏分析。 结果 呼吸道标本(痰和导管)分离出的病原菌以革兰阴性杆菌为主,占80.50%,菌种以鲍氏不动杆菌为主,占27.36%; 革兰阳性球菌占8.20%,以金黄色葡萄球菌为主,占5.53%;真菌占11.23%,以白色假丝酵母菌为主,占8.20%,高于革兰阳性球菌所占比例。病原菌的耐药性较广泛,其中耐甲氧西林金黄色葡萄球菌(MRSA)检出率为28.60%;大肠埃希菌和肺炎克雷伯菌的β-内酰胺酶(ESBLs)检出率分别为58.70%和27.20%;真菌耐药有增高趋势。 结论 ICU患者呼吸系统感染病原菌主要为革兰阴性杆菌,真菌感染有增高趋势。多种抗菌药耐药情况严重,医院应加强病原菌耐药率的监测,指导临床合理使用抗菌药物。
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关 键 词: | 重症监护病房 呼吸道 病原菌分布 耐药率 |
收稿时间: | 2012-08-07 |
Distribution of respiratory infection pathogens and their drug resistance in intensive care unit in hospital, 2010-2011 |
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Abstract: | Objective To understand the distribution of respiratory infection pathogens and their drug resistance in the intensive care unit(ICU) in our hospital and provide evidence for the rational use of antibiotics in clinical practice and effective control of nosocomial infection. Methods Pathogens were isolated from the respiratory samples of the patients with respiratory infection in ICU in our hospital from 2010 to 2011,the identification of the pathogens were conducted by using microbiological analyzer and related drug susceptibility test was done by disk diffusion test(K-B). Results Among the pathogens isolated from the respiratory samples, the majority were gram-negative bacilli, accounting for 80.50%, in which, Acinetobacter baumannii accounted for the largest proportion(27.36%), gram positive coccus accounted for 8.20%, in which 5.53% were Staphylococcus aureus, fungi accounted for 11.23%, in which, 8.20% were Candida albicans. The overall drug resistant rate was high. The detection rate of methicillin-resistant Staphylococcus aureus(MRSA) was 28.60%; The detection rates of Escherichia coli and Klebsiella pneumoniae ESBLs were 58.70% and 27.20%. Conclusion The pathogens detected in the ICU patients with respiratory infection were mainly gram-negative bacilli, and fungal infections tended to increase. Multi drug resistance was serious. It is necessary to strengthen the surveillance of pathogens’ drug resistance to guide clinical antibiotic use. |
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