Lymphocyte diversity in a 9-year-old boy with idiopathic CD4+ T cell lymphocytopenia |
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Authors: | Frühwirth M Clodi K Heitger A Neu N |
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Institution: | Department of Pediatrics, University of Innsbruck, School of Medicine, Innsbruck, Austria. |
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Abstract: | Since CD4+ lymphocytopenia can be caused by disturbed thymic T-cell maturation, we investigated the T-cell subsets of a 9-year-old boy fulfilling the diagnostic criteria for CD4+ lymphocytopenia in a follow-up period of 4 years. We found (I) reduced CD45RA expression, (II) enhanced CD45RO expression and (III) a significant increase in gamma delta TCR-bearing T cells. An accelerated apoptosis (11%) was observed in the CD45RO+, but not CD45RA+ subset. These findings provide evidence that a disturbed thymic T-cell maturation process might play a role in the pathogenesis of CD4+ lymphocytopenia. |
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