青光眼局部降眼压药专家共识和一线药物的发展

青光眼局部降眼压药物有六大类，临床指南中关于药物治疗的建议有利于指导青光眼治疗时的合理用药，尤其是目标眼压的确立及一线药物的选择。总体趋势是前列腺素类药物（PGA）将作为原发性开角型青光眼局部降眼压一线药物。起始治疗后单药疗效不能达到目标眼压时可转换药物、增加药物、激光或手术治疗。转换药物的指征为起始治疗不能降低眼压或降低幅度不够，后者也可增加药物。PGA对前房角部分关闭者的降眼压需进一步评价。临床用药的选择路径应是一个从规范化到个体化的过程。（眼科，2012，21：11-13）

The advances of the expert consensus and the first-line medications of topical intraocular pressure-lowering agents in glaucoma treatment

There are six main classifications and thousands of all combination schemes of topical intraocular pressure-lowering agents currently available in management of glaucoma.The clinical guidelines have kept renewing in recent years aiming to guide the clinical doctors in their maximum reasonable medical therapy.In the present paper,the selection path of drug application and the expert consensus from 2011 World Glaucoma Congress are briefly introduced,with the target intraocular pressure and the first-line medications as a center.