慢性腹泻患者食物特异性IgG抗体的检测

目的探讨食物不耐受与慢性腹泻发病的相关性。方法采用ELISA半定量法检测82例慢性腹泻患者血清中14种食物的水平。结果慢性腹泻患者所测食物中以蟹的IgG抗体阳性率（48．8％）最高，其次为虾（41．5％）、蛋清／蛋黄（35．4％）和牛奶（23．2％），再次为鳕鱼（19．5％）和小麦（17．1％）；≤50岁年龄组腹泻患者食物IgG抗体阳性率明显高于〉50岁年龄组（P〈0．05）；慢性腹泻患者食物特异性IgG抗体检测的总阳性率为89．0％（73／82），其中1种食物IgG抗体阳性率为30．5％（25／82），2种以上者为58．5％（48／82）。结论食物不耐受是慢性腹泻的致病因素之一，检测食物特异性IgG抗体对于了解慢性腹泻的发病机制和指导临床治疗具有积极的意义。

Detection of specific IgG antibodies of food intolerance in patients with chronic diarrhea

Objective To explore the correlation between food intolerance and chronic diarrhea. Methods The food intolerance specific IgG antibodies in serum were measured by enzyme-linked immunosorbent assay（ELISA） in 82 patients with chronic diarrhea. Results The most common elevated food intolerance specific IgG detected was the one against crab （ 48.8% ）, followed by shrimp （ 41.5% ）, egg （35.4%） ,milk（23.2%）,cod（19.5%） and wheat（ 17. 1% ）. The total positive rate of the test was 89.0% （73/82）, and 30.5% （25/82） of the patients showed elevated levels of one type of antibodies and 58.5% （48/82） of the patients showed at least 2 types of antibodies. Conclusion Food intolerance is an important etiological factor. Detection of specific IgG antibodies of food intolerance is significant for understanding pathogenesy of chronic diarrhea and direct clinical treatment.