| The role of 131Ⅰ in the apoptosis of thyrocytes of patient with Graves' disease |
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| 作者姓名： | 冯小妍 李险峰 刘建中 赵德善 张承刚 李思进 蔡敏 |
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| 作者单位： | 太原市中心医院核医学科;山西医科大学第一医院核医学科,030001; |
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| 摘 要： | The changes of Fas.FasL and Bcl-2 expression in thyrocytes of patients with Graves'disease were investigated before and 2 weeks after 131Ⅰ administration. The results showed that 131Ⅰ couhl induce thyrocytes to express the apoptotic protein Fas, FasL and the anti-apoptotic protein Bet-2 in patients with Graves'disease. A statistically significant correlation was found between the dose of 131Ⅰ and the expression levels of Fas and FasL but not Bet-2 ,suggesting that early onset of hypothyroid after 131Ⅰ administration may be due to the increased expression of Fas and FasL in thyrocytes.
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| 关 键 词： | 格雷夫斯病 131Ⅰ治疗 细胞凋亡 凋亡蛋白 131Ⅰ therapy |
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