满山香子抗炎成分研究

 目的从满山香子(seed of Schisandra propinqua(Wall)Hook.f.et Thom s.)中分离、鉴定化学成分。方法通过体积分数为75%乙醇提取,利用硅胶柱色谱、Sephadex LH-20柱色谱和制备薄层色谱的方法对满山香子提取物进行分离,并通过¹H-NMR,¹³C-NMR鉴定化合物的结构。结果从满山香子中分离鉴定出6个化合物:均三苯甲酸(trimesic acid,Ⅰ)、柚皮素(nar-ingenin,Ⅱ)、大黄素甲醚(physcion,Ⅲ)、6-乙基-5-羟基-2,7-二甲氧基-1,4-萘醌(6-ethyl-5-hydroxy-2,7-d imethoxy-1,4-naphtho-quinone,Ⅳ)、乌苏酸(ursolic acid,Ⅴ)和十九碳酸(nonadecanoic acid,Ⅵ)。结论化合物Ⅰ,Ⅱ,Ⅲ,Ⅳ和Ⅵ系首次从5味子科中分得,化合物Ⅴ为首次从该植物中分得。

Study on the Antiphlogistic Constituents in Seed of Schisandra propinqua(Wall)Hook.f.et Thorns

OBJECTIVE To isolate and characterize chemical constituents from the seed of Schisandra propinqua(Wall)Hook.f.et thoms.METHODS The seed of Schisandra propinqua was extracted by 75% ethanol,the extracts were separated by silica gel and Sephadex LH-20 column chromatography and preparative thin-layer chromatography.The structures of the compounds were identified by ¹H-NMR and ¹³C-NMR. RESULTS Six compounds were obtained from seed of Schisandra propinqua,and they are: trimesic acid(Ⅰ),naringenin(Ⅱ),physcion(Ⅲ),6-ethyl-5-hydroxy-2,7-dimethoxy-1,4-naphthoquinone(Ⅳ),ursolic acid(Ⅴ) and nonadecanoic acid(Ⅵ).CONCLUSION Compound 1,2,3,4 and 6 are first isolated from Schisandraceae,compound 5 is the first isolated from Schisandra propinqua.