Different clinical features between patients with ROS1-positive and ALK-positive advanced non-small cell lung cancer |
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| Authors: | Xianxiu Ji Huikang Xie Ren Zhu Bin Chen Sen Jiang Jie Luo |
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| Institution: | 1.Department of Oncology, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China; 2.Department of Pathology, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China; 3.Department of Medical administration, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China; 4.Department of Radiology, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China |
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| Abstract: | ObjectiveTo compare the baseline clinical characteristics between patients with ROS1-positive and ALK-positive advanced non-small cell lung cancer (NSCLC), and the correlations of these subtypes with the distribution of metastases.MethodsWe compared the clinical characteristics and imaging features of patients with ROS1-positive and ALK-positive NSCLC using statistical methods.ResultsData for 232 patients were analyzed. Compared with ALK-positive NSCLC, ROS1-positive NSCLC was more likely to occur in women (71% vs 53%), and primary lesions ≤3 cm were more common in patients with ROS1-positive compared with ALK-positive NSCLC (58% vs 37%). There was no significant difference in the distribution of metastases between the two groups. Subgroup analysis within the ROS1-positive group showed that, compared with primary lesions >3 cm, primary lesions ≤3 cm were more likely to present as peripheral tumors (72% vs 43%) and more likely to exhibit non-solid density (44% vs 4%).ConclusionsAlthough ROS1-positive and ALK-positive NSCLCs show similar clinical features, the differences may help clinicians to identify patients requiring further genotyping at initial diagnosis. |
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| Keywords: | Non-small cell lung cancer c-ros proto-oncogene 1 anaplastic lymphoma kinase clinical feature imaging tumor size |
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