孕妇全氟辛酸暴露因素与稽留流产的相关性研究

目的 探讨孕妇全氟辛酸（perfluorooctanoic acid,PFOA）暴露因素与稽留流产的相关性。方法 根据纳排标准选取扬州市妇幼保健院2020年8月至2021年8月稽留流产孕妇80例为病例组,按1∶1比例同期选取正常早孕终止妊娠的80名妊娠女性为对照组,通过调查问卷了解两组孕妇的人口学及社会学特征,检测两组孕妇的血清PFOA含量,使用统计学方法分析PFOA暴露因素,探讨PFOA暴露与稽留流产发生的关系。结果 烟草暴露、外卖点餐频次、居住于农村及房屋装修在两组孕妇中比较差异有统计学意义（P<0.05）;两组孕妇中居住于农村、经常外卖点餐的孕妇及病例组中入住新装修房屋的孕妇血清PFOA有较高水平的表达;病例组孕妇的血清PFOA值较对照组升高（P<0.05）。结论 烟草暴露、经常外卖点餐、居住于农村、房屋装修可能是导致孕妇孕早期稽留流产的危险因素,稽留流产的发生可能与高水平PFOA暴露有关。

Exposure factors of perfluoroic acid in pregnant women and its correlation with missed abortion

Objective To explore the exposure factors of maternal serum perfluoroctanoic acid (PFOA) and the correlation with the occurrence of missed abortion. Methods According to the inclusion and exclusion criteria, 80 pregnant patients with missed abortion were selected in Yangzhou Maternal and Child Care Service Centre from August 2020 to August 2021 as case group, meanwhile in a 1:1 ratio normal early pregnant women who required induce abortion were selected as control group. We use the questionnaire to collect the demographic and sociological characteristics of two groups of pregnant women, and then detect the serum content of PFOA in two groups of pregnant women, at last we use statistical methods to analysis the factors which affect PFOA exposure and explore the relationship between PFOA exposure and abortion. Results The frequency of tobacco exposure, ordering takeout, rural residence and housing decoration in the two groups were significant (P<0.05); High levels of serum PFOA levels were found in pregnant women, frequently ordered takeout, and pregnant women living in new homes in case group; The serum of PFOA in case group was increased compared with control group (P<0.05). Conclusion Tobacco exposure, frequently takeout, living in rural areas and house decoration may be the risk factors of missed abortion, and the occurrence of missed abortion may be related to the high level of PFOA exposure.