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抗氧化系统对不同年龄患者冠状动脉病变程度的影响
引用本文:杨晖,赵雅洁,沈琳辉,梁伟. 抗氧化系统对不同年龄患者冠状动脉病变程度的影响[J]. 蚌埠医学院学报, 2015, 40(3): 330-333. DOI: 10.13898/j.cnki.issn.1000-2200.2015.03.011
作者姓名:杨晖  赵雅洁  沈琳辉  梁伟
作者单位:1. 上海瑞金医院集团闵行区中心医院 心内科, 上海 201100;2. 上海交通大学医学院附属瑞金医院 老年病科, 上海 200025
基金项目:国家自然基金青年科学基金项目(81100633);上海交通大学“医工(理)交叉研究基金”(YG2011MS39)
摘    要:目的:探讨不同年龄患者过氧化氢酶(CAT)、超氧化物歧化酶 (SOD)以及谷胱甘肽系统对冠状动脉(冠脉)病变程度的影响。方法:选取179例年龄49~90岁的心内科住院患者,分为<60岁组(非老年组)77例,≥60岁组(老年组)102例。测定空腹血脂、血糖、CAT、SOD、还原型谷胱甘肽(GSH)、谷胱甘肽还原酶(GR)、谷胱甘肽过氧化物酶(GSH-Px)等,测量身高、体质量等指标。根据每例患者的冠状动脉造影结果,采用Gensini评分系统对每支血管病变程度进行定量评分。结果:老年组患者血浆CAT、SOD、GSH、GR和GSH-Px水平均低于非老年组患者(P<0.05~P<0.01)。校正年龄因素后,血浆CAT、SOD、GSH、GR和GSH-Px水平与 Gensini积分仍呈显著负相关关系(P<0.01)。多元线性回归分析显示,GSH-Px和CAT对Gensini积分的影响作用更大(P<0.01)。结论:随着年龄增长,血浆CAT、SOD、GSH、GR和GSH-Px明显降低,与冠脉病变程度具有一定的负相关性,且CAT和GSH-Px对冠脉病变的影响作用更大。

关 键 词:冠状动脉疾病   超氧化物歧化酶   过氧化氢酶   谷胱甘肽过氧化物酶   还原型谷胱甘肽   谷胱甘肽还原酶   衰老
收稿时间:2013-11-30

Effect of antioxidant system on the coronary heart disease of different age patients
YANG Hui , ZHAO Ya-jie , SHEN Lin-hui , LIANG Wei. Effect of antioxidant system on the coronary heart disease of different age patients[J]. Journal of Bengbu Medical College, 2015, 40(3): 330-333. DOI: 10.13898/j.cnki.issn.1000-2200.2015.03.011
Authors:YANG Hui    ZHAO Ya-jie    SHEN Lin-hui    LIANG Wei
Affiliation:1. Department of Cardiology, The Central Hospital of Minhang District of Ruijin Hospital Group, Shanghai 201100;2. Department of Gerontology, The Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Abstract:Objective: To investigate the effects of catalase ( CAT), superoxide dismutase ( SOD) and glutathione system on the coronary heart disease of different age patients. Methods:One hundred and seventy-nine 49 to 90 years old patients with coronary heart disease were divided into the non-senile group(77 cases,less than 60 years old) and senile group(102 cases,more than or equal to 60 years old). The levels of fasting lipid,fasting glucose,CAT,SOD,GSH,GSH-Px and GR,height and weight in all cases were measured. The results of coronary arteriography of all cases were assessed using Gensini score system. Results:The serum levels of GSH,GSH-Px, GR,CAT and SOD in senile group were lower than those in non-senile group(P < 0. 05 to P < 0. 01). There was significantly negative correlation between the levels of GSH,GSH-Px,GR,CAT and SOD,and Gensini scores after righting age(P < 0. 01). The results of multiple linear regression analysis showed that the effects of GSH-Px and CAT on Gensini scores were great. Conclusions:The levels of GSH,GSH-PX,GR,CAT and SOD significantly decrease with the growth of age,which is negative correlation with coronary artery disease. The effects of GSH-Px and CAT on coronary artery disease are great.
Keywords:coronary artery disease  superoxide dismutase  catalase  glutathione peroxidase  reduced glutathione  glutathione reductase  senility
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