别嘌呤醇预防氟脲嘧啶为主方案引起的口腔炎

目的观察癌症病人化疗前含漱别嘌呤醇液有否预防氟脲嘧啶（５－ＦＵ）合用醛氢叶酸（ＣＦ）化疗引起口腔炎的效果。方法４３４例恶性肿瘤患者随机分成两组，一组在ＣＦ＋５－ＦＵ化疗前一周连续含漱别嘌呤醇液；另一组单用ＣＦ＋５－ＦＵ作为对照组。结果含漱别嘌呤醇液组发生口腔炎为９．５％，对照组３３．８％，口腔炎发生率预防组显著低于对照组（Ｐ＜０．０１）。结论ＣＦ＋５－ＦＵ化疗前含漱别嘌呤醇液有肯定的预防口腔炎效果。

Allopurinol gargle on the Prevention of fluorouracil induced stamatitis

Objectives To evaluate the effect of allopurinol on the prevention of stamatitis induced by chemotherapy with 5-FU. Methods Four handreds thirty four patients with malignent tumor were randomly into two groups. One group (221 cases) gargled with allopurinol for six days before chemotherapy with CF 5FU (preventive group), another group (213 cases) was as control group that was only received 5-FU CF. Results The rate of stamatitis of chemotherapy of the group that gargled with allopurinol was 9.5%, and that was 33.8% in control group (P<0.01) On the degree of stamatitis, the preventive group was slighter than control group. Conclusions Gargle of allopurinol before chemotherapy can prevent stamatitis induced by 5-FU.