GE TRACERLab FX-FN合成器降低18F-FDG合成成本的研究 |
| |
引用本文: | 何玉林,王雪梅,包宝亮,吴君,赵周社.GE TRACERLab FX-FN合成器降低18F-FDG合成成本的研究[J].内蒙古医学院学报,2012,34(3):217-220. |
| |
作者姓名: | 何玉林 王雪梅 包宝亮 吴君 赵周社 |
| |
作者单位: | 1. 内蒙古医学院附属医院核医学科,内蒙古呼和浩特,010050 2. 通用电器(中国)医疗集团 |
| |
基金项目: | 国家自然科学基金,内蒙古医学院青年基金 |
| |
摘 要: | 目的:研究了GE TRACERLah FX - FN合成器降低18F- FDG(氟18-脱氧葡萄糖、18F]2 - fluoro -2 - deoxy -D - glucose)正电子药物合成成本方法.方法:本实验分别用华益艾素托福公司生产的国产试剂和ABX公司生产的进口试剂盒各合成了18F- FDG四次.对二种试剂盒合成的18F- FDG进行比活度、PH值、放化产率、放射化学与化学纯度和K2.2.2的含量及试剂成本的对照.结果:国产试剂及进口ABX公司试剂盒四次制备的18F - FDG的放化产率平均值分别为:59.25%和60.25%(t=-2.449,P=0.095 >0.05);放射化学纯度平均值分别为:98.75%和99%(t=-1.000,P=0.391>0.05),二者无统计学差异.比活度、pH值、K2.2.2的含量均符合药典要求.国产试剂成本为进口ABX公司试剂盒的成本的1/2.结论:采用华益艾素托福公司试剂合成18F - FDG与进口试剂盒合成的18F-FDG有相同的放化产率、放射化学与化学纯度,而合成成本却比进口试剂盒降低了一半.
|
关 键 词: | 国产试剂盒 ABX公司试剂盒 合成方法 |
THE STUDY OF REDUCING THE SYNTHESIS COST OF 18F-FDG BY GE TRACERLAB FX-FN SYNTHESIZER |
| |
Institution: | HE Yu-lin,WANG Xue-mei,BAO Bao-liang,et al.(Department of Nuclear Medicine,Affiliated Hospital,Inner Mongolia Medical College,Hohhot 010050 China) |
| |
Abstract: | Objective:To reduce the cost of18F-FDG production on TRACERlab FX FN synthesizer.Methods: We produced 8 batches of18F-FDG.In 4 batches we used FDG chemical kit purchased from ABX(containing precursor,chemicals and Sep-Pak SPE column),in other 4 batches we used FDG kit purchased from Huayi Isotope Co.(China).We compared the yield,pH,radio-chemical purity,K2.2.2 residual and production cost of FDG product between ABX and Huayi.Results: 18F-FDG mean yield produced from ABX and Huayi is 60% and 59%,mean radiochemical purity is both 99%,pH value and K2.2.2 redidual both fulfill SFDA demand.However,production cost when using Huayi FDG kit is only half of ABX.Conclusion:the yield and quality of18F-FDG when using Huayi FDG kit as same as ABX,and We reduced half of 18F-FDG production cost.It is good news for China PET center. |
| |
Keywords: | domestic-made kit ABX kit methodology |
本文献已被 CNKI 万方数据 等数据库收录! |
|