| 脑内不同部位颈交感神经节移植后大鼠旋转行为改善的观察 |
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| 引用本文： | 杜建新 板苍辙. 脑内不同部位颈交感神经节移植后大鼠旋转行为改善的观察[J]. 首都医科大学学报, 1993, 14(2): 120-123 |
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| 作者姓名： | 杜建新 板苍辙 |
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| 作者单位： | 首都医学院宣武医院神经外科，日本和歌山医大脑神经外科，首都医学院宣武医院神经外科 |
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| 摘 要： | 大鼠脑内黑质注入六羟基多巴(6-OHDA).使其成为帕金森病的模型后.将大鼠自体颈交感神经节移植入脑内不同部位,以观察其对模型的旋转行为的纠正程度.我们选择了两处移植靶点(尾状核和壳核)进行实验.结果表明颈交感神经节在两处移植点具有相似的效应,均可使模型鼠在注入阿仆吗啡后的单方向旋转强度下降约50%。儿茶酚胺组织荧光检查显示被移植的神经节成活良好.
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| 关 键 词： | 上颈交感神经节 移植 尾状核 壳核 |
| 收稿时间： | 1991-12-09 |
Recovery of Rotational Behavior After SCG Transplantaton in 6-OHDA-Induced Parkinson Model Rat |
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| Du Jianxin Ding Yuji. Recovery of Rotational Behavior After SCG Transplantaton in 6-OHDA-Induced Parkinson Model Rat[J]. Journal of Capital Medical University, 1993, 14(2): 120-123 |
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| Authors: | Du Jianxin Ding Yuji |
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| Affiliation: | Du Jianxin Ding Yuji Department of Neurosurgery,Xuanwu Hospital,Capital Institute of Medicine Itakura T Department of Neurosurgery,Wakayama Hospital,Japan |
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| Abstract: | Autologous superior cervical ganglion transplantation was performed into the different places in rat's brain where the nigro-striatal dopamine system was unilaterally destoried by 6-OHDA injection.Two different locations for grafts were tested,namely the caudate and the putament.Almost the same effect on recovering ratationlal behaviour induced by apo- morphine was acheived in both groups.The intensity of ratation was about 50 per cent de- crease afer grafting.Catecholamine fluroscence histoehemical study showed good survival of grafted tissue. |
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| Keywords: | transplantation superior cervical ganglion putament caudate |
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