Foxp3在子宫内膜、正常早孕和原因不明复发性流产患者蜕膜上的表达

目的:探讨Foxp3在增生期、分泌期内膜和正常早孕、原因不明复发性流产(URSA)患者蜕膜的表达。方法:用免疫组化法观察15例增生期子宫内膜, 12例分泌期子宫内膜, 32例正常早孕和25例URSA患者蜕膜组织Foxp3的表达与分布。结果:增生期子宫内膜无Foxp3表达,分泌期内膜和蜕膜组织均有表达;分泌期内膜Foxp3的表达显著低于正常早孕组(P<0 .01)和URSA组(P<0. 05);URSA患者蜕膜Foxp3的表达显著低于正常早孕组(P<0 .01);Foxp3表达于胞浆,正常早孕组和分泌期内膜主要表达在腺上皮细胞,URSA患者主要表达在间质细胞。结论:Foxp3在分泌期子宫内膜和蜕膜组织的表达可能在胚泡植入和早期妊娠的维持中起重要作用,其表达水平降低可能与URSA的发生有关。

Expression of Foxp3 in human endometrium and decidua of normal early pregnant women and unexplained recurrent spontaneous abortion patients

Objective:To observe the expression of Foxp3 in human endometrium(proliferative phase and secretory phase respectively)and decidua of normal early pregnant women and unexplained recurrent spontaneous abortion(URSA)patients.Methods:By immunohistochemistry,expression and distribution of Foxp3 were observed in 27 cases of human endometrium (15 at proliferative phase and 12 at secretory phase )and 57cases of decidual tissues (32 of normal early pregnant women and 25 of unexplained recurrent spontaneous abortion patients).Results:The expression of Foxp3 were observed in both secretory endometrium and pregnancy decidua,but not observed in proliferative endometrium.The expression of Foxp3 in secretory endometrium were lower significantly than that in normal early pregnant women(P <0.01)and URSA patients(P<0.05).Foxp3 expression were lower significantly in URSA group compared with that in normal pregnancy decidua(P<0.01).The distribution of Foxp3 were mostly in the gland epithelial in both normal pregnant women and secretory endometrium,and mainly in stromal cells in URSA patients.However,they were all localized in the cytoplasm.Conclusion:Expression of Foxp3 in secretory endometrium and decidua is an important factor in the implantation of blastocyst and maintenance of pregnancy.The lower expression of Foxp3 may be involved in the pathogenesis of URSA.