Risk Factors for Clostridioides Difficile Diarrhea In Solid Organ Transplantation Recipients |
| |
Institution: | 1. Departamento de Medicina Interna, Hospital Universitario Puerta de Hierro, Madrid, Spain;2. Biostatistics Unit, Puerta de Hierro Biomedical Research Institute (IDIPHISA), CIBERESP, Madrid, Spain;3. Unidad de Enfermedades Infecciosas, Departamento de Medicina Interna, Hospital Universitario Puerta de Hierro, Madrid, Spain;4. Departamento de Microbiología, Hospital Universitario Puerta de Hierro, Madrid, Spain;5. Departamento de Medicina Preventiva, Hospital Universitario Puerta de Hierro, Madrid, Spain;6. Departamento de Neumología, Hospital Universitario Puerta de Hierro, Madrid, Spain;7. Unidad de Trasplante Hepático, Departamento de Medicina Interna, Universidad Autónoma de Madrid, Hospital Universitario Puerta de Hierro, Madrid, Spain;8. Departamento de Cardiología, Hospital Universitario Puerta de Hierro, Madrid, Spain;9. Departamento de Nefrología, Hospital Universitario Puerta de Hierro, Madrid, Spain;10. Unidad de Enfermedades Infecciosas, Departamento de Medicina Interna, Instituto de Investigación Sanitaria Puerta de Hierro – Segovia de Arana (IDIPHSA), Universidad Autónoma de Madrid, Hospital Universitario Puerta de Hierro, Madrid, Spain |
| |
Abstract: | BackgroundThere is limited knowledge about risk factors for Clostridioides difficile infection (CDI) and recurrent CDI in solid organ transplant (SOT) recipients.MethodsA case-control study of CDI in SOT recipients compared with controls (SOT recipients who did not present CDI).ResultsSixty-seven patients from 1089 SOT recipients (6.2%) suffered at least one episode of CDI. The mean age was 55 ± 12 years and 20 cases (69%) were men. The accumulated incidence was 8% in liver transplantation, 6.2% in lung transplantation, 5.4% in heart transplantation, and 4.7% in kidney transplantation. Twenty-nine cases (43.3%) were diagnosed during the first 3 months after SOT. Forty-one cases (61.2%) were hospital acquired. Thirty-one patients with CDI presented with mild-moderate infection (46.3%), 30 patients with severe infection (44.8%), and 6 patients with severe-complicated disease (9%). Independent variables found to be related with CDI were hospitalization in the previous 3 months (odds ratio: 2.99; 95% confidence interval 1.21-7.37]) and the use of quinolones in the previous month (odds ratio: 3.71 95% confidence interval 1.16-11.8]). Eleven patients (16.4%) had at least one recurrence of CDI. Previous treatment with amoxicillin-clavulanate, severe-complicated index episode, and high serum creatinine were associated with recurrent CDI in the univariant analysisConclusionsLiver transplant recipients presented the highest incidence of CDI among SOT recipients. Risk factors for CDI were hospitalization in the previous 3 months and the use of quinolones in the previous month. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|