Prognostic significance of TP53 expression for patients with hepatocellular carcinoma: a meta-analysis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Prognostic significance of TP53 expression for patients with hepatocellular carcinoma: a meta-analysis

Authors:	Ping Zhan Ya-Nan Ji

Affiliation:	1.First Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing 210029, China; 2.Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing 210029, China

Abstract:	Background Various studies evaluated the relationship between p53 expression and the clinical outcome in patients with hepatocellular carcinoma (HCC), but yielded conflicting results. Methods Electronic databases updated to Dec 2013 were searched to find relevant studies. A meta-analysis was conducted with eligible studies which quantitatively evaluated the relationship between p53 expression and survival of patients with HCC. Survival data were aggregated and quantitatively analyzed. Results We performed a meta-analysis of 24 studies that evaluated the correlation between p53 expression and survival in patients with HCC. Combined hazard ratios (HRs) suggested that p53 expression had an unfavorable impact on overall survival (OS) [HR =1.64, 95% confidence interval (CI): 1.40-1.85], and disease free survival (DFS) (HR =1.57, 95% CI: 1.26-1.87) in patients with HCC. Conclusions p53 expression indicates a poor prognosis for patients with HCC.

Keywords:	TP53 expression hepatocellular carcinoma (HCC) prognosis meta-analysis