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Taurine supplementation associated with exercise increases mitochondrial activity and fatty acid oxidation gene expression in the subcutaneous white adipose tissue of obese women
Affiliation:1. School of Physical Education and Sport of Ribeirao Preto, University of Sao Paulo –EEFERP USP, Ribeirao Preto, Sao Paulo, Brazil;2. Internal Medicine Department, Ribeirao Preto Medical School, University of Sao Paulo – FMRP USP, Ribeirao Preto, Sao Paulo, Brazil;3. State University of Minas Gerais – UEMG, Divinopolis, Minas Gerais, Brazil;4. Department of Food and Nutrition, School of Pharmaceutical Sciences of Araraquara, State University of Sao Paulo – FCF UNESP, Araraquara, Sao Paulo, Brazil;5. Department of BioMolecular Sciences, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo – FCFRP USP, Ribeirao Preto, Sao Paulo, Brazil;6. Laboratory of Molecular Biology of Exercise, University of Campinas – FCA UNICAMP, Limeira, Sao Paulo, Brazil;1. Emergency Department, Clermont-Ferrand University Hospital, Clermont-Ferrand, France;2. Université Clermont Auvergne, Clermont-Ferrand, France;3. Biostatistics Unit, DRCI, Clermont-Ferrand University Hospital, Clermont-Ferrand, France;4. Service de Nutrition Clinique, CHU Clermont-Ferrand, Unité de Nutrition Humaine, INRA, Université Clermont Auvergne, 63003, Clermont-Ferrand, France;5. Université Clermont-Auvergne, Unité de Nutrition, CRNH, Clermont-Ferrand, France;6. Université Clermont Auvergne, INRAE, UNH, Unité de Nutrition Humaine, Clermont-Ferrand, France;7. Université Clermont Auvergne, CHU Clermont-Ferrand, Laboratoire de Pharmacologie et Toxicologie, Clermont-Ferrand, France;8. Service d''Hématologie Biologique, CHU Clermont-Ferrand, Clermont-Ferrand, France;9. Centre de Ressources et Compétences des Maladies Hémorragiques Constitutionnelles, CHU Clermont-Ferrand, Clermont-Ferrand, France;10. School of Exercise Science, Australian Catholic University, Melbourne, VIC, Australia;11. UMR CNRS 6024, “Physiological and Psychosocial Stress” Team, LAPSCO, Clermont-Ferrand, France;1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan;2. Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan;3. Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan;4. Rong Hsing Research Center for Translational Medicine, Institute of Biomedical Science, National Chung Hsing University, Taichung, Taiwan;5. Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan;1. Division of Cardiology, Ospedale degli Infermi, ASL Biella, Italy;2. Department of Translational Medicine, Azienda Ospedaliera-Universitaria “Maggiore della Carità”, Eastern Piedmont University, Novara, Italy;3. Department of Cardiology, UMC St Radboud, Nijmegen, the Netherlands;1. Cardio-Diabetes and Core Lab Unit, Diabetes Research Institute, Department of Internal Medicine, IRCCS San Raffaele Institute, Via Olgettina 60, 20132, Milan, Italy;2. Cardio-Metabolism and Clinical Trials Unit, Diabetes Research Institute, Department of Internal Medicine, IRCCS San Raffaele Institute, Via Olgettina 60, 20132, Milan, Italy;1. Department of Blood Transfusion, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China;2. Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;3. Health Management Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China;1. Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, People''s Republic of China;2. Department of Clinical Nutrition, The First Affiliated Hospital of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou, 510080, People''s Republic of China;3. Sun Yat-sen University, 74 Zhongshan Second Road, Guangzhou, Guangdong, 510080, People''s Republic of China;4. Department of Radiation Oncology, First People''s Hospital of Foshan, Foshan, People''s Republic of China;5. Department of Radiation Oncology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangdong, 510630, People''s Republic of China
Abstract:Taurine supplementation only increased the expression of fat oxidation genes (ACO2 and ACOX1). Exercise increased energy metabolism and the expression of fat oxidation genes in the subcutaneous white adipose tissue. The association between taurine supplementation and exercise promoted additional effects to exercise by increasing energy expenditure, and upregulating mitochondrial respiratory capacity and the expression of genes related to mitochondrial metabolism and fat oxidation in the subcutaneous adipose tissue (scWAT) of obese women.
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Keywords:Taurine  Exercise  White adipose tissue  Mitochondrial metabolism
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