Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis

Diabetes has been associated with periodontitis, but the mechanisms through whichperiodontal diseases affect the metabolic control remain unclear.

Objective

This study aimed to evaluate serum leveis of inflammatory markers, IL-8, IL-6 andmonocyte chemoattractant protein 1 (MCP-1), in type 2 diabetic patients in thepresence of chronic periodontitis.

Material and Methods

Forty two individuals were enrolled in this study and assigned to one of fivegroups: diabetes mellitus with inadequate glycemic control and periodontitis(DMI+P, n = 10), diabetes mellitus with adequate glycemic control andperiodontitis (DMA+P, n = 10), diabetes mellitus without periodontitis (DM, n =10), periodontitis without diabetes (P, n=6), and neither diabetes norperiodontitis (H, n = 6). Periodontal clinical examination included visible plaqueindex (PL), gingival bleeding index (GB), probing depth (PD), attachment level(AL) and bleeding on probing (BP). Glycemic control was evaluated by serumconcentration of glycated hemoglobin (HbAlc). Inflammatory serum markers IL-8,IL-6 and (MCP-1) were measured by ELISA.

Results

DMI+P and DMA+P groups presented higher PD (p=0.025) and AL (p=0.003) values whencompared to the P group. There were no significant differences among groups forIL-6, IL-8 and MCP-1 serum levels.

Conclusions

Although periodontitis was more severe in diabetic patients, the serum levels ofthe investigated inflammatory markers did not differ among the groups.