Functional variants in the promoter region of macrophage migration inhibitory factor rs755622 gene (MIF G173C) among patients with heart failure: Association with echocardiographic indices and disease severity |
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| Institution: | 1. Department of Medical Biochemistry& Molecular Biology, Faculty of Medicine, Assiut University, Egypt;2. Department of Cardiology, Faculty of Medicine, Assiut University, Egypt;1. Emergency Intensive Care Unit, Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China;2. Department of Intensive Care Unit, Yiwu Hospital Affiliated to Wenzhou Medical University, Yiwu 322000, PR China;3. Department of Nephrology, Yiwu Hospital Affiliated to Wenzhou Medical University, Yiwu 322000, PR China;1. Department of Internal Medicine, McGovern Medical School, Houston, TX, USA;2. Department of Advanced Cardiopulmonary Therapeutics and Transplantation, McGovern Medical School, Houston, TX, USA;3. Department of Internal Medicine: Renal Diseases and Hypertension, McGovern Medical School, Houston, TX, USA;4. Department of Internal Medicine: Pulmonary, Critical Care and Sleep Medicine, McGovern Medical School, FCCP, 6431 Fannin St MSB 1.268, 77030 Houston, TX, USA;1. Division of Cardiovascular Emergencies, University of Napoli \"Federico II\", Italy;2. Division of Obstetrics and Gynaecology, University of Napoli \"Federico II\", Italy;3. Division of Cardiovascular Perfusion, The Royal Brompton, London, UK;1. Intensive Care Unit, Poissy Saint Germain Hospital, 9-10 rue du champ Gaillard, Poissy 78300, France;2. Medical Intensive Care Unit, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France;3. INSERM U-1018, CESP, Team “Epidemiologie Clinique”, UVSQ, Villejuif, France;1. Department of Cardiovascular Center, Zhongshan People''s Hospital, Zhongshan 528403, PR China;2. Department of Laboratory Diagnosis Center, Zhongshan People''s Hospital, Zhongshan 528403, PR China;3. DepartmenLit of Intensive care Medicine, Zhongshan People''s Hospital, Zhongshan 528403, PR China |
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| Abstract: | BackgroundHeart failure (HF) is a serious public health concern resulting in death. An individual predisposition to HF is determined by relationship between genetic and environmental variables. The macrophage migration inhibitory factor (MIF) is a significant mediator that involved in a variety of inflammatory and cardiovascular diseases. To reveal contribution of MIF rs755622 G173C gene variants in the promoter region towards HF pathogenesis and investigate association between recognized genotype and clinical characteristics.Patients and methodsWe recruited 90 patients with HF, 63 with preserved ejection fraction (HFpEF) and 27 with reduced ejection fraction (HFrEF), and 60 age- and sex- matched controls. MIF rs755622 (G>C) single-nucleotide polymorphism was genotyped by PCR-RFLP method.ResultsThe GG genotype of MIF rs755622 gene polymorphism was more frequent in HF patients than in controls which increased the risk of HF by about 4.25 times (p<0.05). The distribution of the GG, GC and CC genotypes of MIF were 42%, 21% and 0.0% among HFrEF, and 33.3%, 55.6% and 11.1% among HFpEF respectively. Higher frequency of MIF rs755622 G allele among HFrEF (100%) compared to HFpEF (88.9%) (p = 0.007). MIF-GG genotype variant had significantly lower LVEF. In multivariate analysis, MIF-GG genotype was independent risk predictor among HF (OR 4.6).ConclusionMIF rs755622 (GG) could be considered as a probable genotypic risk factor for HF, especially in those with HFrEF which increases the possibility that MIF contribute to HF progression. MIF genotype assay may serve as early predictor and help to recognize those at great risk of developing HF. |
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