Serological and molecular study of Leptospira in pediatric patients at a tertiary care centre of northern India |
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| Institution: | 1. Institute of Biosciences and Technology, Shri Ramswaroop Memorial University and Department of Microbiology, King George''s Medical University, Lucknow, Uttar Pradesh, India;2. Institute of Biosciences and Technology, Shri Ramswaroop Memorial University, Lucknow, Uttar Pradesh, India;3. Department of Microbiology, King George''s Medical University, Lucknow, Uttar Pradesh, India;4. Departments of Pediatrics, K.G.M.U., Lucknow, Uttar Pradesh, India;5. Department of Medicine, K.G.M.U., Lucknow, Uttar Pradesh, India;6. Division of Bacteriology and Mycology, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India;7. Department of Centre for Integrative Medicine & Research, AIIMS, New Delhi, India;1. Department of Microbiology, All India Institute of Medical Sciences (AIIMS), New Delhi, India;2. Department of Orthopedics, All India Institute of Medical Sciences (AIIMS), New Delhi, India;3. Department of Biostatistics, All India Institute of Medical Sciences (AIIMS), New Delhi, India;1. Department of Clinical Microbiology, Rainbow Children''s Hospital, India;2. Department of Gastroenterology, Rainbow Children''s Hospital, India;1. Department of Microbiology Faculty of Medicine and Allied Sciences Rajarata University of Sri Lanka, Saliyapura, Sri Lanka;2. Teaching Hospital, Kandy, Sri Lanka;1. Dept. of Anaesthesiology & Intensive Care, GIPMER, New Delhi, India;2. Dept. of Psychiatry, GIPMER, New Delhi, India |
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| Abstract: | Leptospirosis is considered as one of the most neglected zoonotic tropical diseases. Animals and humans acquire this infection through direct contact with contaminated urine or body fluids of infected animals. This prospective study was undertaken to know the proportion of leptospirosis in pediatric patients presented with acute febrile illness at the Post Graduate Department of Microbiology, King George's Medical University, Lucknow, Uttar Pradesh. Blood samples were collected over a period of one year from January to December 2018 from 70 pediatric patients aged up to 0–12 years presented with febrile illness for 3–14 days. Out of the 70 samples, 7 (10%) samples were found positive by IgM ELISA, 4 (5.7%) samples were positive by MAT and 3(4.3%) were found positive by PCR. Risk factors such as contact with infected animals and contaminated environment were highly associated with seropositivity of leptospirosis. Clinical symptoms such as fever, chills, myalgia, headache, abdominal pain and cough were significantly associated (p < 0.05) with the seropositivity of leptospirosis. |
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| Keywords: | Molecular diagnosis Leptospirosis Pediatrics Neglected disease Febrile illness |
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