Teprotumumab: Interpreting the Clinical Trials in the Context of Thyroid Eye Disease Pathogenesis and Current Therapies |
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| Affiliation: | 1. Department of Ophthalmology, University of California, San Francisco, San Francisco, California;2. Ophthalmology Section, Surgical Service, San Francisco Veterans Affairs Medical Center, San Francisco, California |
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| Abstract: | |
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| Keywords: | thyroid eye disease Graves' disease Graves' orbitopathy Translational science review biologics Teprotumumab clinical activity score randomized clinical trial AE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" adverse event CAS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" clinical activity score DON" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" dysthyroid optic neuropathy FDA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" Food and Drug Administration GD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" Graves’ disease GO-QoL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" Graves’ Ophthalmopathy Quality of Life IBD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" inflammatory bowel disease IGF-1" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" insulin-like growth factor 1 IGF-1R" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" insulin-like growth factor 1 receptor IL-6" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" interleukin-6 ITT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0160" }," $$" :[{" #name" :" text" ," _" :" intention-to-treat ORT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0170" }," $$" :[{" #name" :" text" ," _" :" orbital radiotherapy PI3K" },{" #name" :" keyword" ," $" :{" id" :" kwrd0180" }," $$" :[{" #name" :" text" ," _" :" phosphatidylinositol 3-kinase RANTES" },{" #name" :" keyword" ," $" :{" id" :" kwrd0180d" }," $$" :[{" #name" :" text" ," _" :" regulated upon activation, normal T cell expressed and presumably secreted TBII" },{" #name" :" keyword" ," $" :{" id" :" kwrd0190" }," $$" :[{" #name" :" text" ," _" :" thyrotropin-binding inhibitory immunoglobulin TED" },{" #name" :" keyword" ," $" :{" id" :" kwrd0200" }," $$" :[{" #name" :" text" ," _" :" thyroid eye disease TNF-α" },{" #name" :" keyword" ," $" :{" id" :" kwrd0210" }," $$" :[{" #name" :" text" ," _" :" tumor necrosis factor α TSI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0220" }," $$" :[{" #name" :" text" ," _" :" thyroid -stimulating immunoglobulins TSHR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0210b" }," $$" :[{" #name" :" text" ," _" :" thyrotropin receptor |
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