Anti-Inflammatory and Anti-Superbacterial Properties of Sulforaphane from Shepherd's Purse |
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Authors: | Woo Jin Choi Seong Keun Kim Hee Kuk Park Uy Dong Sohn Wonyong Kim |
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Affiliation: | 1.Department of Microbiology, College of Medicine, Chung-Ang University, Seoul 156-861, Korea.;2.College of Pharmacy, Chung-Ang University, Seoul 156-861, Korea. |
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Abstract: | Shepherd''s purse, Capsella bursa-pastoris (L.) Medik., has been considered a health food for centuries in Asia and is known to contain the isothiocyanate compound sulforaphane. In this study, we evaluated the anti-inflammatory and antibacterial properties of a sulforaphane-containing solution (SCS) isolated from shepherd''s purse. SCS had significant anti-inflammatory activity indicated by the decreased levels of nitric oxide (NO), cytokines (interleukin 1β IL-1β], IL-6, and IL-10), and prostaglandin E2 (PGE2) in lipopolysaccharide-stimulated RAW 264.7 murine macrophages. In addition, SCS decreased the inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2) levels, which confirmed the anti-inflammatory activity of SCS. Further, SCS inhibited vancomycin-resistant enterococci (VRE) and Bacillus anthracis. The minimal inhibitory concentration was 250 µg/ml for VRE and 1,000 µg/ml for B. anthracis. Taken together, these data indicate that SCS has potential anti-inflammatory and anti-superbacterial properties, and thus it can be used as a functional food or pharmaceutical. |
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Keywords: | Anti-inflammatory effect Antimicrobial activity Cytokine RAW 264 7 murine macrophages Shepherd''s purse Sulforaphane |
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