Association of N-terminal pro-brain natriuretic peptide level with adverse outcomes in patients with acute myocardial infarction: A meta-analysis |
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| Institution: | 1. Department of Cardiology, Tongde Hospital of Zhejiang Province, Hangzhou City, Zhejiang Province, 310012, PR China;2. Department of Intensive Medicine, Tongde Hospital of Zhejiang Province, Hangzhou City, Zhejiang Province, 310012, PR China;1. Cardiology Department, University Hospital of Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Paseo San Vicente, 58-182, 37007 Salamanca, Spain;2. CIBER-CV Instituto de Salud Carlos III (ISCIII), Spain;1. Department of Thoracic and Cardiovascular Surgery, Gyeongsang National University College of Medicine and Gyeongsang National University Changwon Hospital, 11, Samjeongja-ro, Seongsan-gu, Changwon 51472, Republic of Korea;2. Department of Thoracic and Cardiovascular Surgery, Gyeongsang National University College of Medicine and Gyeongsang National University Jinju Hospital, Jinju, Republic of Korea;3. Department of Neurosurgery, Gyeongsang National University College of Medicine and Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea;1. Department of Intensive Care, Austin Hospital, Melbourne, VIC, Australia;2. Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Australia;3. Dipartimento di Scienze dell''emergenza, anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy;4. Università Cattolica del Sacro Cuore, Rome, Italy;5. Department of Intensive Care, Siriraj Hospital, Mahidol University, Bangkok, Thailand;6. Service de médecine intensive et réanimation, hôpital de la Croix Rousse, Hospices Civils de Lyon, Lyon, France;7. Centre for Integrated Critical Care, School of Medicine, University of Melbourne, Parkville, Victoria, Australia;1. Department of Cardiology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India;2. Department of Pathology, Holy Family Hospital, New Delhi, India;3. Department of Medicine, SG Diabetes Center, New Delhi, India;4. Department of Pulmonary, Critical Care and Sleep Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India;1. Núcleo de Ensino Pesquisa e Extensão em Fisioterapia no Pré e no Pós-Operatório de Cirurgias de Grande Porte da UDESC (PREPARA/UDESC), Brazil;2. Programa de Pós-Graduação em Fisioterapia da UDESC (PPGFT/UDESC), Brazil;3. Programa de Pós Graduação em Ciência do Movimento Humano da UDESC (PPGCMH/UDESC), Brazil;4. Universidade do Estado de Santa Catarina (UDESC) - Florianópolis (SC), Paschoal Simone, 358, Coqueiros, Florianópolis 88080-350, Brazil |
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| Abstract: | BackgroundStudies evaluating the association of blood level of N-terminal pro-brain natriuretic peptide (NT-proBNP) with adverse prognosis have yielded conflicting results in patients with acute myocardial infarction (AMI). This meta-analysis sought to evaluate the prognostic value of blood level of NT-proBNP in patients with AMI.MethodsTwo authors independently searched articles in PubMed and Embase databases up to June 13, 2021. Studies evaluating the association of baseline NT-proBNP level with all-cause mortality or major adverse cardiovascular events (MACEs, including death, new or worsening heart failure, recurrent myocardial infarction, revascularization, stroke, etc.) among AMI patients were selected. Multivariable-adjusted risk ratio (RR) with 95% confidence interval (CI) was pooled by the highest vs. lowest category of NT-proBNP level.ResultsA total of 19 studies enrolling 12,158 AMI patients were identified. When compared highest with the lowest category of NT-proBNP level, the pooled RR was 5.28 (95% CI 2.87–9.73) for in-hospital/30-day death, 2.62 (95% CI 2.04–3.37) for follow-up all-cause mortality, and 2.50 (95% CI 1.91–3.28) for follow-up MACEs, respectively. Subgroup analysis further confirmed the value of NT-proBNP in predicting all-cause mortality and MACEs.ConclusionsElevated NT-proBNP level is independently associated with an increased risk of all-cause mortality and MACEs. Determination of blood NT-proBNP level can improve risk stratification of AMI patients. |
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