Marine n-3 polyunsaturated fatty acids lower plasma proprotein convertase subtilisin kexin type 9 levels in pre- and postmenopausal women: A randomised study |
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| Affiliation: | 1. Department of Cardiology, Aalborg University Hospital, Sdr. Skovvej 15, 9000 Aalborg, Denmark;2. Department of Nephrology, Aalborg University Hospital, Molleparkvej 4, 9000 Aalborg, Denmark;1. Consorci d''Atenció Primària de Salut Eixample (CAPSE), Grup Transversal de Recerca en Atenció Primària, Institut d''Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain;2. Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain;3. Lipid Clinic, Department of Endocrinology and Nutrition, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain;4. Diagnostic Imaging Centre, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain;1. Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR) and Departamento de Ciencias Biológicas, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Ocampo y Esmeralda, Predio CONICET Rosario, 2000 Rosario, Argentina;2. Dept. of Biochemistry, Dokkyo Medical University School of Medicine, Japan;3. Departamento de Ciencias Biológicas, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Ocampo y Esmeralda, Predio CONICET Rosario, Rosario, 2000, Argentina |
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| Abstract: | ObjectiveTo investigate whether a supplement of 2.2 g of marine n-3 polyunsaturated fatty acids (PUFA) influences plasma proprotein convertase subtilisin kexin type 9 (PCSK9) levels in pre- and postmenopausal women.MethodsNinety-two healthy women were randomly assigned to consume 2.2 g marine n-3 PUFA or a control oil (thistle oil) daily for 12 weeks. Adipose tissue, a long-term marker of dietary intake of seafood was collected at baseline and blood samples were drawn at baseline and after 12 weeks of supplement intake.ResultsPlasma PCSK9 levels were significantly reduced by 11.4% for premenopausal women and 9.8% for postmenopausal women after the supplement of 2.2 g of marine n-3 PUFA compared with control oil. The mean change of plasma PCSK9 levels between participants receiving marine n-3 PUFA and control oil was 16.1% for premenopausal women and 13.1% for postmenopausal women. There was, however, no correlation between baseline levels of plasma PCSK9 and the fatty acid content of marine n-3 PUFA in adipose tissue.ConclusionThis study showed that 2.2 g marine n-3 PUFA reduce plasma PCSK9 levels in both pre- and postmenopausal women. |
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