Cardiac isoform of alpha 2 macroglobulin, an early diagnostic marker for cardiac manifestations in AIDS patients |
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Authors: | Ramasamy Subbiah Omnath Reghunath Rathinavel Andiappan Kannan Perumal Dhandapany Perundurai S Annapoorani Ponnambalam Balakumar Pitchai Singh Manjeet Ganesh Rajagopalan Selvam Govindan Sadasivam |
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Affiliation: | Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamilnadu, India. |
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Abstract: | This study investigated the possible role of the cardiac isoform of alpha 2-macroglobulin (CA2M) as an early diagnostic marker for HIV-associated cardiovascular manifestations. A total of 349 samples were analysed by Western blot and quantified by sandwich enzyme-linked immunosorbent assay. The levels of CA2M present in sera of HIV-associated cardiac diseases were significantly higher than those of HIV without cardiac involvement and healthy sera. CA2M may act as a novel diagnostic marker to identify cardiac manifestations in HIV/AIDS patients. |
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