| 诱导痰嗜酸性粒细胞与慢性持续期哮喘病情严重程度的关系 |
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| 引用本文： | 王法霞,赖克方,陈桥丽,罗炜,陈如冲,李斌恺,钟南山. 诱导痰嗜酸性粒细胞与慢性持续期哮喘病情严重程度的关系[J]. 中华肺部疾病杂志(电子版), 2010, 3(1): 6-9 |
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| 作者姓名： | 王法霞 赖克方 陈桥丽 罗炜 陈如冲 李斌恺 钟南山 |
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| 作者单位： | 广州医学院第一附属医院,广州呼吸疾病研究所,广州,510120 |
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| 摘 要： | 目的观察并探讨初诊不同病情严重程度慢性持续期哮喘患者的诱导痰嗜酸性粒细胞(Eos)比例变化,以及诱导痰Eos比例与肺功能的相关性。方法收集专科门诊就诊的63例初诊慢性持续期哮喘患者,根据症状分为轻度持续、中度持续、重度持续3组,分别予诱导痰和肺功能检查。观察不同病情严重程度的患者气道炎症状况。对所得数据用SPSS15.0软件分析,各组间总体分析采用Kruskal-Wallis法,两组间分析采用Mann-Whitney U法。采用Spearman rank-order法分析Eos比例与肺功能的相关性。结果①慢性持续期患者诱导痰Eos比例随病情严重程度增加呈增高趋势,重度持续患者诱导痰Eos比例显著高于轻度持续患者(41.8%vs17.8%,P=0.033),但轻度持续与中度持续、中度持续与重度持续患者之间比较诱导痰Eos比例均无显著差异(P0.05);②诱导痰Eos比例与FEV1无显著相关(r=-0.111,P0.05),与FEV1/FVC(%)无显著相关(r=-0.154,P0.05)。结论慢性持续期哮喘患者病情严重程度与诱导痰Eos比例有关,但症状不能完全反映气道炎症程度。评价哮喘患者的严重程度时应结合临床症状和气道炎症程度综合考虑。
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| 关 键 词： | 哮喘 气道炎症 诱导痰 嗜酸性粒细胞 肺功能 |
The relationship between persistent asthma severity and eosinophil percentage in induced sputum |
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| WANG Faxia,LAI Kefang,CHEN Qiaoli,LUO Wei,CHEN Ruchong,LI Binkai,ZHONG Nanshan. The relationship between persistent asthma severity and eosinophil percentage in induced sputum[J]. Chinese Journal of lung Disease（Electronic Edition）, 2010, 3(1): 6-9 |
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| Authors: | WANG Faxia LAI Kefang CHEN Qiaoli LUO Wei CHEN Ruchong LI Binkai ZHONG Nanshan |
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| Affiliation: | WANG Faxia,LAI Kefang,CHEN Qiaoli,LUO Wei,CHEN Ruchong,LI Binkai,ZHONG Nanshan. (State Key Laboratory of Respiratory Disease,Guangzhou Institute of Respiratory Diseases,The First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,China)Corresponding author: LAI Kefang. E-mail:klai@163.com |
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| Abstract: | Objective To observe and investigate the eosinophil(Eos) percentage of induced sputum in persistent asthma with different severity and stable stages, and the correlation between Eos percentage and lung function. Methods The 63 patients with persistent asthma newly diagnosed were recruited from special clinic. The range of disease severity was classified into mild, moderate and severe persistent according to the symptoms. Sputum was induced by hypertonic saline aerosol inhalation, and lung function was exame... |
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| Keywords: | Asthma Airway inflammation Induced sputum Eosinophil Lung function |
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