肾病综合征表现的局灶性节段性肾小球硬化的远期预后分析

本文将针对25年来治疗局灶性节段性肾小球硬化的一项区域性儿童肾脏病协作计划进行系统回顾.所有患儿经肾穿刺诊断为局灶性节段性肾小球硬化,其中大部分为美国黑人患儿,与之前报道的患同样疾病以白人为主体的患儿比较,他们的临床特点和远期预后均有不同.由于亚洲和非洲的肾病患儿局灶性节段性肾小球硬化的发生率均较高,因此中国患儿可能在疾病的临床特征、对治疗的反应和远期预后等方面与本文所讨论的美国黑人患儿类似.

Nephrotic syndrome due to focal segmental glomerulosclerosis:Long-term outcomes

Lessons learned over 25 years from treating focal segmental glomerulosclerosis(FSGS)in a regional pediatric nephrology program will be reviewed.In a cohort of children with biopsy-proven FSGS,consisting of a large percentage of African-American patients,the clinical characteristics and long-term outcomes are different from previously published data on mostly white children with the same condition.Because Asian and African children with nephrotic syndrome have the same higher incidence of FSGS,it is possible that Chinese children with FSGS have clinical characteristics,therapeutic responses,and long-term outcomes similar to African-American children as reviewed in this article.