| 海洛因滥用者血清中细胞因子、一氧化氮含量变化的研究 |
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| 引用本文： | 何德 刘仿 等. 海洛因滥用者血清中细胞因子、一氧化氮含量变化的研究[J]. 中国药物依赖性杂志, 2001, 10(4): 281-282 |
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| 作者姓名： | 何德 刘仿 等 |
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| 作者单位： | 广东医学院检验系，广东医学院检验系，广东医学院检验系 湛江，524023，湛江，524023，湛江，524023 |
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| 基金项目： | 广东医学院青年科学基金资助课题 (NO.199812) |
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| 摘 要： | 目的··:探讨海洛因滥用者血清中细胞因子、一氧化氮 (NO)含量的变化。方法·· :采用放射免疫法 ,检测50例海洛因滥用者血清中细胞因子、NO含量并与正常人比较。结果··:海洛因滥用者血清中IL -1、IL -2和TNF含量明显低于正常人 (P<0.01) ,NO含量非常显著高于正常人 (P<0.001)。结论·· :海洛因滥用者血清中细胞因子含量降低和NO含量显著升高与免疫功能损害密切相关
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| 关 键 词： | 海洛因滥用 细胞因子 免疫功能 一氧化氮 |
STUDY ON THE CHANGES OF CYTOKINES AND NO LEVELIN SERUM OF HEROIN ABUSERS |
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| HE De,LIU Fang,GUO Zhen. STUDY ON THE CHANGES OF CYTOKINES AND NO LEVELIN SERUM OF HEROIN ABUSERS[J]. Chinese Journal of Drug Dependence, 2001, 10(4): 281-282 |
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| Authors: | HE De LIU Fang GUO Zhen |
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| Abstract: | Objective: To investigate the changes of IL-1?IL-2?TNF and NO level in serum of heroin abusers. Method: IL-1?IL-2?TNF and NO levels were determined by radioimmunoassay in 50 heroin abusers and 40 non-heroin abusers as control. Result: Cytokines (IL-1?IL-2?TNF) level in serum of heroin abuse group significantly decreased (P<0.01) and NO was higher than that of the control (P<0.001).Conclusion: The immunofunction (containing specific immunity and nonspecific immunity)of heroin abusers is lower than that of the non-heroin abusers, which is probably due to the decrease of cytokines. |
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| Keywords: | heroin abuser cytokine immunofunction |
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