Decrease of cerebral mast cell degranulation after systemic administration of lipopolysaccharide |
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| Authors: | David Dubayle Anne Héron |
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| Institution: | 1. Laboratory of Neurophysics and Physiology, CNRS UMR 8119, Paris Descartes University, 45 Rue Des Saints Pères, 75270, Paris, France
2. Experimental, Metabolic and Clinical Biology Department, Faculty of Phamaceutical Sciences, Paris Descartes University, 4 Avenue de L’Observatoire, 75270, Paris, France
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| Abstract: | Introduction The mast cell is an immunocyte, but its functions in the brain remain unclear. Materials and methods In a rat model of weak inflammation, we analyzed the effect of a gram-negative bacterial lipopolysaccharide injection (100?μg/kg) on thalamic mast cell (MC) population. Conclusion We demonstrate a significant decrease of their degranulation, which suggests the implication of MC in preventing sepsis on the brain. |
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