急性脑梗塞患者血清白细胞介素6的变化及其临床意义

目的　研究急性脑梗塞患者血清白细胞介素６（ＩＬ－６） 的变化，进而探讨其临床意义。方法　采用放免法检测４０ 例急性脑梗塞患者血清ＩＬ－６ 水平，并与２０ 例健康人作对照。结果　脑梗塞患者急性期血清ＩＬ－ ６ 水平明显高于恢复期（Ｐ＜０－０１） 。恢复期血清ＩＬ－６ 稍高于正常水平，与正常对照组比较无显著性差异（ Ｐ＞０－０５） 。急性期血清ＩＬ－ ６ 升高的程度与梗塞灶大小密切相关。结论　脑梗塞急性期血清ＩＬ－６ 升高，恢复期已降至基本正常。脑缺血、缺氧及脑组织损伤引起的急性应激反应可能是脑梗塞急性期血清ＩＬ－６ 升高的重要机制。ＩＬ－６ 升高对缺血神经元可能具有保护作用。

Change and the clinical significant of interleukin - 6 in serum of patients with acute cerebral infarction

Objective To investigate the change of interleukin-6(IL-6)in serum of patients with acute cerebral infarction (ACI),so as to explore the clinical significant .Methods Serum IL-6 levels of 40 ACI patients were assaied by using radioimmunoassay method ,compared with normal control group including 20 cases .Results This study showed that serum IL-6 levels of ACI patients in acute stage were significantly higher than those in recovery stage ( P <0 01).Serum IL-6 levels in recovery stage were slightly higher than those in normal control group, and the difference between two groups was not statistically significant ( P >0 05).The increased serum IL-6 level had significant correlation with the size of infarction Conclusion The results suggested that serum IL-6 levels of ACI patients were increased in acute stage and were decreased to normal in recovery stage .Acute stress response induced by cerebral hypoxia-ischemia and cerebral damage may be the important mechanism of increasing serum IL-6 levels of patients with ACI in acute stage .The increased serum IL-6 might play some role in protecting ischemic neurons . [