| HCV对HIV/AIDS患者高效抗逆转录病毒治疗效果的影响 |
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| 引用本文： | 张永宏,吴昊,蒋岩,陈新月,肖瑶,徐莲芝.HCV对HIV/AIDS患者高效抗逆转录病毒治疗效果的影响[J].首都医学院学报,2004,25(3):329-331. |
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| 作者姓名： | 张永宏 吴昊 蒋岩 陈新月 肖瑶 徐莲芝 |
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| 作者单位： | 首都医科大学附属北京佑安医院
(张永宏，吴昊，陈新月)，中国疾病预防控制中心性病艾滋病预防控制中心
(蒋岩，肖瑶)，首都医科大学附属北京佑安医院(徐莲芝) |
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| 基金项目： | 国家十五科技攻关课题 ( 2 0 0 1BA70 5B0 1)，北京市科委基金 (H0 10 2 10 12 0 113 )，首都医科大学基础临床结合课题 ( 0 3JL10 )资助项目 |
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| 摘 要： | 为探讨丙型肝炎病毒 (HCV)对人类免疫缺陷病毒 /艾滋病 (HIV/AIDS)患者高效抗逆转录病毒治疗(HAART)效果的影响 ,动态观察HIV/HCV重叠感染组和单独HIV感染组患者接受HAART治疗前后免疫功能、病毒载量的变化。发现 :重叠感染组与单独感染组比较 ,治疗前、治疗后 3、6个月的免疫功能、病毒载量均无明显差异(P >0 .0 5 ) ;但是免疫功能动态变化情况差异显著 (P =0 .0 1 7) :重叠感染组CD4 + 上升 ( 4 7.87± 48.42 )个 /μL ,单独感染组上升 ( 1 46.1 2± 88.2 9)个 /μL。提示 :接受正规HAART治疗后 ,重叠感染HCV的HIV/AIDS患者的免疫功能重建滞后于单独HIV感染者
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| 关 键 词： | 人免疫缺陷病毒(HIV) 丙型肝炎病毒(HCV) CD4+T淋巴细胞 免疫重建 |
| 收稿时间： | 2003-09-25 |
| 修稿时间： | 2003年9月25日 |
Effect of HCV Infection on HAART in HIV/AIDS Patients |
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| Zhang Yonghong,Wu Hao,Jiang Yan,Chen Xinyue,Xiao Yao,Xu Lianzhi.Effect of HCV Infection on HAART in HIV/AIDS Patients[J].Journal of Capital University of Medical Sciences,2004,25(3):329-331. |
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| Authors: | Zhang Yonghong Wu Hao Jiang Yan Chen Xinyue Xiao Yao Xu Lianzhi |
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| Institution: | 1. Beijing Youan Hospital, Affiliate of Capital University of Medical Sciences;2. Chinese Centers for Disease Control and Prevention |
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| Abstract: | The aim was to explore the impact of HCV infection to effect of HAART in HIV/AIDS patients.Patients were divided into two groups, HIV/HCV co-infection group and the group of HIV infection alone.Comparisons of the two groups were made on the change of immune function and HIV viral load at the points of pre-cure, month 3, month 6.There were no significant differences in immune function and HIV viral load at three points above between HIV/HCV co-infection and HIV alone(P> 0.05).But significant differences were found in the change of immune function from pre-cure to month 6.The rising of CD4+T was (47.87±48.42)cells/μL in HIV/HCV co-infection group, but (146.12±88.29)cells/μL in HIV infection alone (P=0.017).After cure of HAART the reconstruction of immune function in HIV/HCV co-infection patients is inferior to patients with HIV infection alone. |
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| Keywords: | HIV virus hepatitis C virus CD 4 T cell immune reconstruction |
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