| 鼠尾藻多酚的抗凝血活性研究 |
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| 引用本文： | 李敬,魏玉西,杜桂彩,胡迎芬,李丽.鼠尾藻多酚的抗凝血活性研究[J].中药新药与临床药理,2007,18(3):191-194. |
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| 作者姓名： | 李敬 魏玉西 杜桂彩 胡迎芬 李丽 |
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| 作者单位： | 1. 中国科学院海洋研究所,山东青岛,266071
2. 青岛大学生物系,山东青岛,266071 |
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| 基金项目： | 山东省优秀中青年科学家科研奖励基金 |
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| 摘 要： | 目的探讨鼠尾藻多酚STP-1和STP-2的抗凝血活性。方法体内实验分别以毛细管法、剪尾法测定鼠尾藻多酚对小鼠凝血时间、出血时间的影响;体外实验分别测定鼠尾藻多酚对新西兰兔血浆活化部分凝血活酶时间、血浆凝血酶原时间、血浆凝血酶时间的影响。结果鼠尾藻多酚STP-1在体内、体外均有显著的抗凝血作用,而且中剂量组(1.0mg/mL)抗凝血活性最佳。结论鼠尾藻多酚STP-1在体内、外均有抗凝血活性。
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| 关 键 词： | 鼠尾藻 多酚 抗凝血活性 |
| 文章编号： | 1003-9783（2007）03-0191-03 |
| 收稿时间： | 2006-09-08 |
| 修稿时间： | 2006年9月8日 |
Anticoagulant Activities of Phlorotannins from Sargassum thunbeergii Kuntze |
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| LI Jing,WEI Yuxi,DU Guicai,HU Yingfen,LI Li.Anticoagulant Activities of Phlorotannins from Sargassum thunbeergii Kuntze[J].Traditional Chinese Drug Research & Clinical Pharmacology,2007,18(3):191-194. |
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| Authors: | LI Jing WEI Yuxi DU Guicai HU Yingfen LI Li |
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| Institution: | 1. Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, Shandong; 2 Biological Department of Qingdao University, Qingdao 266071, Shandong |
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| Abstract: | Objective To investigate the anticoagulant activities of phlorotannins STP-1 and STP-2 from Sargassum thunbeergii Kuntze.Methods Coagulation time(CT)and bleeding time(BT)of mice were determined by in-vivo experiment to test the effect of phlorotannins by capillary method and cutting tail method respectively.Furthermore,activated partial thromboplastin time(APTT),prothrombin time(PT)and thrombin time(TT)were measured to evaluate the in-vitro anticoagulant activity of phlorotannins on New Zealand rabbits.Results Phlorotannins STP-1 had a significant effect on the prolongation of CT,BT,APTT,PT and TT,especially at the dosage of 1.0 mg/mL.Conclusion Phlorotannins STP-1 has both in-vivo and in-vitro anticoagulant activity. |
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| Keywords: | Sargassum thunbeergii Kuntze Phlorotannins Anticoagulant activity |
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