| 探讨MUC1基因多态性与胃癌遗传易感性的关系 |
| |
| 引用本文： | 黄冠男,刁玉荃,姜相君.探讨MUC1基因多态性与胃癌遗传易感性的关系[J].中华临床医师杂志(电子版),2013(23):35-37. |
| |
| 作者姓名： | 黄冠男 刁玉荃 姜相君 |
| |
| 作者单位： | [1] 青岛大学医学院附属青岛市立医院消化内二科, 山东省266000 [2] 青岛大学医学院附属青岛市立医院急诊科, 山东省266000 |
| |
| 摘 要： | 目的：探讨 MUC1基因多态性与胃癌遗传易感性的关系。方法采用病例对照研究对150例胃癌患者（胃癌组）和150名健康查体正常者（对照组）的MUC1基因rs2070803单核苷酸多态性进行检测，并分析其与胃癌易感性之间的关系。结果 MUC1基因rs2070803位点3种基因型GG、GA、AA在胃癌病例组中频率分别为80.7%、16.0%和3.3%，而在对照组中分别为64.7%、32.0%和3.3%。与GG型比较，GA/AA型基因型者胃癌发生的危险性降低，OR值为0.439（0.259～0.742）。结论 MUC1基因rs2070803位点GG、GA基因型降低汉族人群的胃癌易感性。
|
| 关 键 词： | MUC1基因 多态性 单核苷酸 胃肿瘤 |
Relationships between the rs2070803 polymorphism of the MUC1 gene and susceptibility to gastric cancer |
| |
| HUANG Guan-nan,DIAO Yu-quan,JIANG Xiang-jun.Relationships between the rs2070803 polymorphism of the MUC1 gene and susceptibility to gastric cancer[J].Chinese Journal of Clinicians(Electronic Version),2013(23):35-37. |
| |
| Authors: | HUANG Guan-nan DIAO Yu-quan JIANG Xiang-jun |
| |
| Institution: | HUANG Guan-nan, DIAO Yu-quan, JIANG Xiang-jun |
| |
| Abstract: | Objective To investigate the relationships between the rs2070803 polymorphism of the MUC1 gene and susceptibility to gastric cancer. Methods A case-control study was used to conducted to investigate whether the polymorphism rs2070803 in MUC1 might be associated with risk of gastric cancer in 150 incident cases with gastric cancer and 150 controls recruited in a Chinese population. Results The data showed that, In rs2070803, the frequency of GG genotype was 80.7%in gastric cancer patients and 64.7%in normal controls, GA genotype was associated with a decrease in risk to an adjusted OR of 0.393 （95%CI 0.225-0.685） and rs2070803 GA/AA to0.439（95% CI 0.259-0.742）. Conclusion The rs2070803 in MUC1 gene are associated with reduced susceptibility to gastric cancer and may play a protective role in a Chinese population. |
| |
| Keywords: | MUC1 gene Polymorphism single nucleotide Stomach neoplasms |
| 本文献已被 维普 等数据库收录！ |
