| NLRP1和NLRP3炎性体的研究进展 |
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| 引用本文： | 原孟,尚丽新. NLRP1和NLRP3炎性体的研究进展[J]. 中华临床医师杂志(电子版), 2013, 0(23): 266-268 |
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| 作者姓名： | 原孟 尚丽新 |
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| 作者单位： | 北京军区总医院妇产科,100700 |
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| 摘 要： | 炎性体作为一种新近发现的蛋白质复合物，其活化后可促进炎性因子的成熟与释放，在先天性免疫中发挥着重要的作用。本文就核苷酸结合寡聚化结构域样受体蛋白1（NLRP1）和3（NLRP3）炎性体的构成、激活机制及信号传导通路和相关的疾病做出综述，并对NLRP1和NLRP3炎性体与早产的关系做出推测。
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| 关 键 词： | 早产 先天性免疫应答 NLRP1 NLRP3 NLRP1 NLRP3 |
Research progress of the NLRP1, NLRP3 inflammasome |
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| YUAN Meng,SHANG Li-xin. Research progress of the NLRP1, NLRP3 inflammasome[J]. Chinese Journal of Clinicians(Electronic Version), 2013, 0(23): 266-268 |
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| Authors: | YUAN Meng SHANG Li-xin |
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| Affiliation: | YUAN Meng, SHANG Li-xin |
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| Abstract: | Inflammasome as a newly discovered protein complexes which can activate promote the maturation and release inflammatory factors plays an important role in innate immunity response. The paper mainly reviewed about the composition, activation mechanism, the signal transduction pathways and the disease of nucleotide-binding oligomerization domain-like receptor protein 1 （NLRP1） and 3 （NLRP3）. And speculated the relationship between the inflammasome NLRP1, NLRP3 and preterm labor. |
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| Keywords: | Premature birth Innate immunity response |
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