超声造影引导下915MHz微波经皮消融活体犬肾动脉活动性出血的止血研究

目的：比较915 MHz经皮微波消融与药物注射对肾动脉活动性出血的止血效果。方法制造肾动脉活动性出血模型并分组：A：d＜1 mm（被膜下动脉）；B：1 mm＜d＜2 mm（叶间动脉），C：2 mm＜d＜3 mm（段动脉），分别行超声造影引导下915 MHz微波治疗与药物注射治疗，比较两者的止血成功率、止血作用时间及静脉补液量，并比较其病理结果。结果 A组两种方法均可有效止血，B组和C组915 MHz微波止血的成功率明显高于药物注射疗法（P＜0.05）。915 MHz微波各组止血时间均显著短于药物注射组A组（125±18.2）s，B组（187±33.4）s，C组（309±39.1）s vs. A组（187±23.9）s，B组（266±26.7）s，C组（413±31.4）s]（P均〈0.05）；静脉补液量也显著小于药物注射组A组（34±14.3）ml，B组（104±3.8）ml， C组（421±8.2）ml vs. A组（89±26.4）ml，B组（157±5.7）ml，C组（607±8.6）ml]（P均＜0.05）。结论超声造影引导下915 MHz微波与药物注射相比具有更好的止血作用。

Study of percutaneous coagulation therapy of 915 MHz microwave for the renal artery injury guided by contrast ultrasound in vivo dogs

Objective To compare the effect of 915 MHz microwave ablation and drug injection on renal artery hemostasis in vivo dogs. Methods The renal artery hemorrhage model was made and grouped A：d〈l mm （subcapsular artery）; B：I mm〈d〈2mm （interlobar arteries）, C：2mm〈d〈3mm （section artery）, 915MHz microwave and drug injection guided by contrast-enhanced ultrasound were performed. The success rate of hemostasis, the time needed for hemostasis, intravenous rehydration volume and pathology results of two therapies were compared. Results In group A, two methods could both stop bleeding effectively, but in group B and C, the success rate of hemostasis of 915 MHz microwave was higher than that of drug injection（P〈0.05）. The time needed for hemostasis in all groups of 915 MHz microwave were all much less than those of drug injectiongroup A （125± 18.2）s, group B （187±33.4）s, group C （309±39.1）s vs. group A （187±23.9）s, group B（266±26.7）s, group C （413±31.4）s]（P 〈0.05）. Intravenous rehydration volume in all groups of 915 MHz microwave were all much less than those of drug injectiongroup A （34±14.3） ml, group B （104±3.8） ml, group C （421±8.2） ml vs. group A （89±26.4） ml, group B （157±5.7） ml, group C （607±8.6） ml]（P〈0.05）. Conclusion 915 MHz microwave guided by ultrasound has better hemostatic effect in comparison with drug injection.