短期应用泮托拉唑对阿司匹林联合氯吡格雷治疗急性ST段抬高型心肌梗死疗效的影响

目的：探讨短期应用泮托拉唑对阿司匹林联合氯吡格雷治疗急性ST段抬高型心肌梗死疗效的影响。方法入选我院心内科首次发生症状并住院成功行急诊PCI治疗的急性ST段抬高型心肌梗死患者207例，按双抗血小板（阿司匹林＋氯吡格雷）治疗时是否联用泮托拉唑将患者分为两组即联用泮托拉唑组（PPIs 组）以及未联用泮托拉唑组（对照组），观察患者的消化道出血事件以及 MACE 事件。结果消化道出血事件主要发生在患者入院后1周内，PPIs组与对照组比较有统计学差异（P＜0.05）；两组患者MACE事件的发生率比较无统计学差异（P＞0.05）。结论短期应用泮托拉唑并没有增加急性 ST 段抬高型心肌梗死患者MACE事件的发生率，同时还能降低消化道出血的发生风险，在临床上特别是针对高危人群值得推广应用。

Effect for short-term application of pantoprazole in patients with acute ST-segment elevation myocardial infarction treated by aspirin and clopidogrel

Objective To observe the efficacy of Short-term application of pantoprazole in patients with acute ST-segment elevation myocardial infarction（STEMI） treated by aspirin and clopidogrel. Methods 207 consecutive acute STEMI patients with the first occurrence of symptoms and hospitalization were randomly divided into two groups： combined treatment group（Aspirin＋clopidogrel＋pantoprazole）; control group（Aspirin＋clopidogrel）. Observe the gastrointestinal bleeding events and major cardiovascular events（MACE）. Results Gastrointestinal bleeding events of both groups mostly occurred in one week, and there were significant differences（P〈0.05）;there were no significant difference between the two groups for incidence of MACE. Conclusion Short-term application of pantoprazole in patients with acute STEMI did not increase the incidence of MACE, simultaneously reducing the risk of gastrointestinal bleeding. It should be widely applied clinically, especially for high-risk groups.