| ERAP1基因多态性与非小细胞肺癌遗传易感性的关联研究 |
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| 引用本文： | 曹丹凤,马千里,周竞贤,钱旭,李盈甫,俞建昆,姚宇峰,史荔. ERAP1基因多态性与非小细胞肺癌遗传易感性的关联研究[J]. 中华临床医师杂志(电子版), 2013, 0(22): 41-43 |
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| 作者姓名： | 曹丹凤 马千里 周竞贤 钱旭 李盈甫 俞建昆 姚宇峰 史荔 |
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| 作者单位： | [1]中国医学科学院北京协和医学院医学生物学研究所云南省重大传染病疫苗研发重点实验室,昆明650118 [2]昆明医科大学第三附属医院胸外科 ,昆明650118 [3]昆明市延安医院心血管外科 ,昆明650118 [4]昆明医科大学第一附属医院干疗科,昆明650118 |
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| 基金项目： | 云南省应用基础研究（2012FB064,2013FZ131） |
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| 摘 要： | 目的：探讨内质网氨肽酶1（endoplasmic reticulum aminopeptidase 1，ERAP1）基因多态性与非小细胞肺癌（non-small cell lung cancer，NSCLC）的相关性。方法入选NSCLC患者224例，健康体检人群207例。采用Taq Man探针基因分型方法对ERAP1基因SNP rs26653和rs26618两个位点进行基因分型，并构建单倍型，评估上述两个SNPs及单倍型与NSCLC的相关性。结果病例组和对照组ERAP1基因rs26618和rs26653基因型和等位基因频率差异有统计学意义（P＜0.05）。病例组和对照组rs26618/rs26653单倍型CG、TC的单倍型频率差异有统计学意义（P＜0.05）。结论 ERAP1基因与NSCLC的发生有关， rs26618/rs26653-CG单倍型可能增加NSCLC的患病风险，rs26618/rs26653-TC单倍型对NSCLC可能具有保护性作用。
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| 关 键 词： | 癌，非小细胞肺 内质网 氨肽酶类 多态性，单核苷酸 单倍性 |
ERAP1 genetic polymorphisms are associated with susceptibility of non-small cell lung cancer |
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| CAO Dan-feng,MA Qian-li,ZHOU Jing-xian,QIAN Xu,L,Ying-fu,YU Jian-kun,YAO Yu-feng,SHI Li. ERAP1 genetic polymorphisms are associated with susceptibility of non-small cell lung cancer[J]. Chinese Journal of Clinicians(Electronic Version), 2013, 0(22): 41-43 |
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| Authors: | CAO Dan-feng MA Qian-li ZHOU Jing-xian QIAN Xu L Ying-fu YU Jian-kun YAO Yu-feng SHI Li |
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| Affiliation: | . Institute of Medical Biology, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research ＆ Development on Severe Infectious Disease, Kunming 650118, China |
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| Abstract: | Objective To evaluate the association between the genetic polymorphisms of endoplasmic reticulum aminopeptidase 1 （ERAP1） and the susceptibility of non-small cell lung cancer （NSCLC） in Chinese Han population. Methods 224 patients with NSCLC and 207 healthy controls in Chinese Han were included in present study. Using TaqMan fluorescence probe technique, the SNPs of rs26618 and rs26653 in ERAP1 gene were genotyped, and rs26618 and rs26653 haplotypes were constructed. Then, the association between the two SNPs with NSCLC was assessed. Results The genotypic and allelic frequencies of rs26618, rs26653 showed significant difference between NSCLC patients and the control groups （all P〈0.05）. The frequencies of haplotype rs26618/rs26653-CG and TC also showed difference between NSCLC patients and the control groups （all P〈0.05）. Conclusion ERAP1 rs26618, rs26653 had a strong association with NSCLC. The rs26618/rs26653-CG haplotype was associated with increased NSCLC risk, whereas rs26618/rs26653-TC haplotype showed a protective effect in NSCLC patients. |
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| Keywords: | Carcinoma, non-small-cell lung Endoplasmic reticulum Aminopeptidases Polymorphism,single nucleotide Haploidy |
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