幽门螺杆菌感染与2型糖尿病患者颈动脉斑块的关系

目的：通过比较2型糖尿病（T2DM）患者中幽门螺杆菌（Hp）感染阳性组与阴性组之间颈动脉斑块（CP）的发生率，探讨Hp感染与T2DM患者CP的相关性以及CP形成的危险因素。方法通过对195例T2DM患者进行13碳尿素呼气试验（13C-UBT）以评估Hp感染与否，将患者分为感染组及非感染组，并进一步将试验组分为轻度感染组、中度感染组和重度感染组，运用彩色多普勒超声仪了解各组颈动脉斑块（CP）情况，同时测定各组患者HCY、LDL、Fbg、TC、Hs-CRP水平进行比较。结果 Hp感染组其颈动脉斑块的发病率大于Hp感染阴性组（P＜0.05）；感染组和非感染组Hs-CRP的差异有统计学意义（P＜0.05）；Logistic回归分析显示：Hp感染是T2DM患者发生CP的危险因素之一；Hp感染程度对CP检出率无影响。结论幽门螺杆菌感染阳性的T2DM患者可能有更高的颈动脉斑块发生率，这一结果与HCY、LDL、Fbg、TC水平无关；Hp感染是T2DM患者发生CP的危险因素；Hp感染的严重程度对T2DM患者的CP发生率无明显影响。

Relationship of heHcobacter pylori infection and carotid plaques in patients with type.2 diabetes mellitus

Objective By comparing the incidence of Carotid plaques（CP） in Helicobacter pylori （Hp） infection-positive group（experimental group） and negative group （control group）, this paper explored the correlation between Hp infection and CP In patients with type 2 diabetes mellitus（T2DM）, and to analyze the related factors of CP. Methods 13C-Urea Breath Test （13C-UBT） was used to assess Hp infection or not. Based on the results of the breath test, a total of 195 patients with T2DM were divided into infection-positive group and infection-negative group. The experimental group was further divided into mild infection, moderate infection and severe infection. Color Doppler ultrasonography was used in each group to detect CP and to measure HCY, LDL, FBG, TC and Hs-CRP for comparison. Results The incidence rate of CP was greater in HP infection-positive group compared to Hp infection-negative group（P〈0.05）. The difference of Hs-CRP in the infection-positive group and infection-negative group was statistically significant（P〈0.05）. Logistic regression analysis showed that HP infection was correlated with CP in patients with T2DM. The severity of HP infection has no significant effect on the incidence of CP. Conclusion Helicobacter pylori infection-positive patients with T2DM may have a higher incidence of carotid plaque, regardless of HCY, LDL, FBG and TC level. This study showed that HP was correlated with CP.The severity of HP infection has no significant effect on the incidence of CP.