新疆和田地区维吾尔族人的瘦素与代谢综合征的临床研究

目的：研究新疆维吾尔族人瘦素水平与胰岛素抵抗的关系。方法选择新疆和田地区943例维吾尔族人进行瘦素水平测定，根据其瘦素的百分位数（瘦素P35＝0.46 ng/ml，瘦素P65＝1.56 ng/ml）分为3组：Ⅰ组330例（瘦素P35），Ⅱ组286例（瘦素P35~65），Ⅲ组327例（瘦素P65），观察3组的体重指数、腰围、收缩压、舒张压、血糖、血脂、空腹胰岛素和HOMA-IR的变化。结果3组间的年龄、体重指数、腰围、收缩压、舒张压、甘油三酯、空腹胰岛素和 HOMA-IR 的比较具有统计学差异，Ⅲ组的体重指数、腰围、收缩压、舒张压、空腹胰岛素和HOMA-IR水平均较Ⅰ组和Ⅱ组明显升高（P＜0.01）。多元线性回归分析结果提示瘦素与体重指数和HOMA-IR呈正相关，回归方程＝-1.528-0.018腰围＋0.128体重指数＋0.001收缩压＋0.002舒张压＋0.229甘油三酯＋0.245HOMA-IR。结论新疆维吾尔族人的瘦素水平与胰岛素抵抗有关。

Clinical research of association between leptin and metabolic diseases in Xinjiang uygur population

Objective To explore the relationship between leptin and insulin resistance in Xinjiang Uygur population. Methods We performed this study among 943 Uygur population in Xinjiang Hetian area. Three groups were divided according their leptin percentile：Ⅰ（leptin P35）=330; Ⅱ=286 （leptin P35-65）; Ⅲ=327 （leptin P65）. Their body mass index（BMI）, waist circumference（WC）, blood pressure（BP）, blood glucose, triglycerides（TG）, cholesterol and fasting insulin were measured respectively. Results There were significant differences in ages, BMI, WC, SBP, TG, fasting insulin and HOMA-IR among three groups. It reveled that leptin was significantly associated with BMI and HOMA-IR by multiple linear regression analysis. Conclusion There was relationship between leptin and insulin resistance in Xinjiang Uygur population.